Bao Y P, Li N, Smith J S, Qiao Y L
Department of Cancer Epidemiology, Cancer Institute/Chinese Academy of Medical Sciences, Beijing, China.
Int J STD AIDS. 2008 Feb;19(2):106-11. doi: 10.1258/ijsa.2007.007113.
The aim of the study was to determine human papillomavirus (HPV) type-distribution in the cervix of Chinese women, and to estimate the potential future impact of HPV prophylactic vaccines for cervical cancer prevention in China. A total of 32 studies using polymerase chain reaction for HPV detection were included in the meta-analysis, including 2844 invasive cervical cancer (ICC), 820 high-grade squamous intraepithelial lesions (HSIL), 432 low-grade squamous intraepithelial lesions (LSIL) and 2902 women with normal cytology/histology. The overall and type-specific HPV prevalence of 18 HPV types (HPV 6, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 70, 73 and 82 of different cervical stages) were estimated. Overall HPV prevalence was 83.7%, 66.2%, 61.3% and 11.2% in ICC, HSIL, LSIL and normal, respectively. HPV 16 was the predominant type in all cervical stages. Estimated HPV 16/18 positive fractions in ICC, HSIL, LSIL and normal were 69.7%, 45.5%, 32.23% and 4.6%, respectively. HPV-16/18 vaccine has the 69.7% potential prevention in ICC. HPV 58 and 52 were the priority HPV types in Chinese women.
本研究旨在确定中国女性宫颈中人乳头瘤病毒（HPV）的型别分布，并评估HPV预防性疫苗对中国宫颈癌预防的潜在未来影响。共有32项使用聚合酶链反应检测HPV的研究纳入荟萃分析，包括2844例浸润性宫颈癌（ICC）、820例高级别鳞状上皮内病变（HSIL）、432例低级别鳞状上皮内病变（LSIL）以及2902例细胞学/组织学正常的女性。估计了18种HPV型别（HPV 6、16、18、31、33、35、39、45、51、52、56、58、59、66、68、70、73和82）在不同宫颈阶段的总体及型别特异性HPV感染率。在ICC、HSIL、LSIL和正常组中，总体HPV感染率分别为83.7%、66.2%、61.3%和11.2%。HPV 16是所有宫颈阶段的主要型别。在ICC、HSIL、LSIL和正常组中，估计的HPV 16/18阳性率分别为69.7%、45.5%、32.23%和4.6%。HPV-16/18疫苗对ICC有69.7%的潜在预防作用。HPV 58和52是中国女性中的优先HPV型别。
