胰岛素生物合成：其中的铁反应元件（IRE）之谜
Insulin biosynthesis: the IREny of it all.
作者信息
Corbett John A
机构信息
Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104.
出版信息
Cell Metab. 2006 Sep;4(3):175-6. doi: 10.1016/j.cmet.2006.08.007.
PMID:16950132
Abstract
Recent studies have shown that the unfolded protein response (UPR) is essential for the survival of insulin-producing beta cells. Work in this issue of Cell Metabolism (Lipson et al., 2006) identifies a novel role for UPR activation in beta cell function by demonstrating that the UPR effector IRE1 is a positive regulator of glucose-stimulated proinsulin biosynthesis.
摘要
最近的研究表明，未折叠蛋白反应（UPR）对于产生胰岛素的β细胞的存活至关重要。发表于本期《细胞代谢》（Lipson等人，2006年）的研究通过证明UPR效应器IRE1是葡萄糖刺激的胰岛素原生物合成的正向调节因子，确定了UPR激活在β细胞功能中的新作用。
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