从脂肪变性到脂肪性肝炎的滑坡是由甘油三酯还是胆固醇铺就的？
Is the slippery slope from steatosis to steatohepatitis paved with triglyceride or cholesterol?
作者信息
Ginsberg Henry N
机构信息
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
出版信息
Cell Metab. 2006 Sep;4(3):179-81. doi: 10.1016/j.cmet.2006.08.010.
PMID:16950134
Abstract
Accumulation of hepatic lipids has been thought to trigger the inflammation, apoptosis, and fibrosis that characterize progression of hepatic steatosis to steatohepatitis and cirrhosis. In this issue of Cell Metabolism, Marí et al. (2006) provide evidence for excessive mitochondrial free cholesterol as a cause of the progession of steatosis to more severe liver disease.
摘要
肝脏脂质的积累被认为会引发炎症、细胞凋亡和纤维化，这些是肝脂肪变性进展为脂肪性肝炎和肝硬化的特征。在本期《细胞代谢》杂志中，玛丽等人（2006年）提供证据表明，过量的线粒体游离胆固醇是脂肪变性进展为更严重肝脏疾病的一个原因。
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