Department of Gastroenterology, University of Sao Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar n° 255, Instituto Central, # 9159, 05403-000 Sao Paulo, Brazil.
Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):245-51. doi: 10.1586/egh.11.22.
Nonalcoholic fatty liver disease is currently one of the most common forms of liver disease, covering cases from simple steatosis without inflammation, to cases of steatohepatitis and fibrosis, and may lead to liver cirrhosis and hepatocellular carcinoma. The pathophysiology of nonalcoholic fatty liver disease is based on multiple events; changes in the secretion of lipoproteins can lead to steatosis. Liver lipid secretion is mediated by apoB100 and microsomal triglyceride transfer protein (MTP). The pharmacological suppression of MTP is suggested as a possible treatment for hyperlipidemia, although the upregulation of this protein can be a treatment for nonalcoholic steatohepatitis.
非酒精性脂肪性肝病是目前最常见的肝病形式之一，涵盖了从单纯无炎症性脂肪变性到脂肪性肝炎和肝纤维化的病例，并且可能导致肝硬化和肝细胞癌。非酒精性脂肪性肝病的病理生理学基于多种事件；脂蛋白分泌的变化可导致脂肪变性。肝脏脂质的分泌是由载脂蛋白 B100 和微粒体甘油三酯转移蛋白（MTP）介导的。MTP 的药理学抑制被认为是治疗高脂血症的一种可能方法，尽管这种蛋白质的上调可能是治疗非酒精性脂肪性肝炎的一种方法。
