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下肢慢性静脉性溃疡可从手术中获益:173条腿的长期结果

Chronic venous leg ulcers benefit from surgery: long-term results from 173 legs.

作者信息

Obermayer Alfred, Göstl Katharina, Walli Gerald, Benesch Thomas

机构信息

Surgical Department, Wachauklinikum Melk, Melk, Austria.

出版信息

J Vasc Surg. 2006 Sep;44(3):572-9. doi: 10.1016/j.jvs.2006.05.039.

Abstract

OBJECTIVE

The purpose of this retrospective study was to present 7 years of data from operations of currently active, chronic venous leg ulcers (CEAP: C6), focusing on the short- and long-term effects of healing and recurrence and considering concomitant risk factors.

METHODS

Between January 1997 and March 2004, 173 patients (239 legs) with a currently active, chronic venous leg ulcer were surgically treated. The surgical procedures included two main steps: (1) the surgical interruption of reflux in the superficial and perforating veins to reduce venous hypertension in the entire leg and/or the affected area and (2) the surgical procedure involving the ulcer. A total of 123 patients (173 legs) who came to the follow-up were examined. The follow-up period ranged from 3 months to 7 years. The data collection integrated a preoperative examination that included medical history and clinical diagnoses and incorporated measurements such as body mass index, ankle-brachial pressure index, and the neutral position method at the follow-up. The function of the veins was measured with duplex ultrasonography. Finally, the data were analyzed by using various statistical methods, including Kaplan-Meier analysis, Cox regression analysis, and paired t tests.

RESULTS

Initially, ulcer healing occurred in 87% of the cases (151 legs). A total of 13% (22 legs) of the venous ulcers never healed, and recurrent venous ulcers occurred in 5% (9 legs). The Kaplan-Meier analyses of ulcer healing showed a healing rate of 85% in 6 months for all legs. The mean time of healing was 1.5 months. Furthermore, the Kaplan-Meier analyses of ulcer recurrence showed a 1.7% rate of recurrence in 6 months for all legs. The 5-year ulcer recurrence rate was 4.6%. The mean time of recurrence was 70.4 months.

CONCLUSIONS

On the basis of the results from the 7 years of data from functional surgery of venous leg ulcers and as a result of the outcomes of our study, we recommend surgical treatment of venous leg ulcers at any stage. We therefore conclude that surgery is indicated before an ulcer is intractable to treatment. In general, our findings are based on the understanding and identification of the causes and symptoms of venous ulceration and illustrate that standard surgical methods can be applied for the therapy of venous leg ulcers at any stage.

摘要

目的

本回顾性研究旨在呈现7年以来当前仍存在的慢性下肢静脉溃疡(CEAP分级:C6)手术治疗的数据,重点关注愈合和复发的短期及长期影响,并考虑相关危险因素。

方法

1997年1月至2004年3月期间,对173例(239条腿)患有当前仍存在的慢性下肢静脉溃疡的患者进行了手术治疗。手术步骤包括两个主要阶段:(1)手术阻断浅静脉和穿通静脉的反流,以降低整个下肢和/或患区的静脉高压;(2)针对溃疡的手术操作。共有123例患者(173条腿)前来接受随访检查。随访期为3个月至7年。数据收集包括术前检查,其中有病史和临床诊断,并纳入了诸如体重指数、踝肱压力指数以及随访时的中立位法等测量指标。通过双功超声检查测量静脉功能。最后,使用包括Kaplan-Meier分析、Cox回归分析和配对t检验在内的各种统计方法对数据进行分析。

结果

最初,87%的病例(151条腿)溃疡愈合。共有13%(22条腿)的静脉溃疡未愈合,5%(9条腿)出现复发性静脉溃疡。溃疡愈合的Kaplan-Meier分析显示,所有腿在6个月时的愈合率为85%。平均愈合时间为1.5个月。此外,溃疡复发的Kaplan-Meier分析显示,所有腿在6个月时的复发率为1.7%。5年溃疡复发率为4.6%。平均复发时间为70.4个月。

结论

基于下肢静脉溃疡功能性手术7年的数据结果以及我们的研究成果,我们建议在任何阶段对下肢静脉溃疡进行手术治疗。因此,我们得出结论,在溃疡变得难以治疗之前就应进行手术。总体而言,我们的研究结果基于对静脉溃疡病因和症状的理解与识别,并表明标准手术方法可应用于下肢静脉溃疡的任何阶段治疗。

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