反复母婴分离对不同小鼠品系焦虑和抑郁相关表型的影响。
Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains.
作者信息
Millstein Rachel A, Holmes Andrew
机构信息
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 2N09, Rockville, MD 20852, USA.
出版信息
Neurosci Biobehav Rev. 2007;31(1):3-17. doi: 10.1016/j.neubiorev.2006.05.003. Epub 2006 Sep 6.
Genetic factors and early life adversity both play a major role in the etiology of mood and anxiety disorders. Previous studies have shown that postnatal maternal separation (MS) can produce lasting abnormalities in emotion-related behavior and neuroendocrine responses to stress in rodents. The present study sought to examine the effects of repeated MS in eight different inbred strains of mice (129S1/SvImJ, 129P3/J, A/J, BALB/cJ, BALB/cByJ C57BL/6J, DBA/2J, FVB/NJ). Pups were separated from their dam and littermates for 180 min/day ('MS') or 15 min/day ('handling'), or left undisturbed ('facility-reared') from postnatal days P0-P13, and tested as adults for anxiety- and depression-related behaviors. Results demonstrated no clear and consistent effects of MS or handling on behavioral phenotypes in any of the strains tested. In all strains, MS produced an increase in maternal care on reunion with pups, which may have modified MS effects. Data demonstrate that the MS procedure employed does not provide a robust model of early life stress effects on the anxiety- and depression-related behaviors in the mouse strains tested.
遗传因素和早年逆境在情绪及焦虑障碍的病因学中均起主要作用。先前的研究表明，产后母婴分离（MS）可在啮齿动物中产生与情绪相关行为以及对应激的神经内分泌反应的持久异常。本研究旨在检验重复MS对八种不同近交系小鼠（129S1/SvImJ、129P3/J、A/J、BALB/cJ、BALB/cByJ、C57BL/6J、DBA/2J、FVB/NJ）的影响。幼崽在出生后第0至13天被与其母鼠和同窝幼崽分离180分钟/天（“MS”）或15分钟/天（“处理”），或不被打扰（“饲养在设施中”），成年后测试其与焦虑和抑郁相关的行为。结果表明，在任何测试品系中，MS或处理对行为表型均无明确且一致的影响。在所有品系中，MS导致母鼠与幼崽重聚时母性照料增加，这可能改变了MS的影响。数据表明，所采用的MS程序并不能为早年应激对所测试小鼠品系中与焦虑和抑郁相关行为的影响提供一个可靠的模型。
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