Walker Shakeera L, Glasper Erica R
Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, United States; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, 43210, United States.
Department of Neuroscience, The Ohio State University, Columbus, OH, 43210, United States; Neuroscience Graduate Program, The Ohio State University, Columbus, OH, 43210, United States; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, 43210, United States.
Front Neuroendocrinol. 2025 Jan;76:101162. doi: 10.1016/j.yfrne.2024.101162. Epub 2024 Nov 17.
Early-life stress (ELS) affects the development of prosocial behaviors and social-cognitive function, often leading to structural brain changes and increased psychosocial disorders. Recent studies suggest that mother- and father-child relationships independently influence social development in a sex-specific manner, but the effects of impaired father-child relationships are often overlooked. This review examines preclinical rodent studies to explore how parental neglect impacts neuroplasticity and social behaviors in offspring. We highlight that disruptions in maternal interactions may affect male pups more in uniparental rodents, while impaired paternal interactions in biparental rodents tend to impact female pups more. Due to limited research, the separate effects of maternal and paternal neglect on brain development and social behaviors in biparental species remain unclear. Addressing these gaps could clarify the sex-specific mechanisms underlying social and neurobiological deficits following parental neglect.
早年生活应激（ELS）会影响亲社会行为和社会认知功能的发展，常常导致大脑结构变化以及心理社会障碍增加。近期研究表明，母子关系和父子关系以性别特异性方式独立影响社会发展，但父子关系受损的影响往往被忽视。本综述考察了临床前啮齿动物研究，以探讨父母忽视如何影响后代的神经可塑性和社会行为。我们强调，在单亲啮齿动物中，母体互动中断可能对雄性幼崽影响更大，而在双亲啮齿动物中，父体互动受损往往对雌性幼崽影响更大。由于研究有限，双亲物种中母体和父体忽视对大脑发育和社会行为的单独影响仍不清楚。填补这些空白可能会阐明父母忽视后社会和神经生物学缺陷背后的性别特异性机制。
