果蝇翅膀中渐次变化的痕迹器官表达模式对生长和位置信息的控制。
Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster.
作者信息
Baena-Lopez L A, García-Bellido A
机构信息
Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid Edificio Ciencias, CX-504 28049 Madrid, Spain.
出版信息
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13734-9. doi: 10.1073/pnas.0606092103. Epub 2006 Sep 1.
Abstract
The size and shape of organs depend on cellular processes such as cell proliferation, cell survival, and spatial arrangement of cells. In turn, all of these processes are a consequence of positional identity of individual cells in whole organs. Links of positional information with organ growth and pattern expression of genes is a little-addressed question. We show that differences in vestigial expression between neighboring cells of the wing blade autonomously and nonautonomously affect cell proliferation along the proximo-distal axis. On the other hand, uniform expression of vestigial inhibits cell proliferation and also perturbs the shape of wing blade altering the preferential orientation of cell divisions. Our observations provide evidence that local cell interactions, triggered by differences in vestigial expression between neighboring cells, confer positional values operating in the control of growth and shape of the wing.
摘要
器官的大小和形状取决于细胞增殖、细胞存活以及细胞空间排列等细胞过程。反过来，所有这些过程都是整个器官中单个细胞位置身份的结果。位置信息与器官生长和基因模式表达之间的联系是一个鲜有涉及的问题。我们发现，翼片相邻细胞之间残翅基因表达的差异会自主且非自主地影响沿近远轴的细胞增殖。另一方面，残翅基因的均匀表达会抑制细胞增殖，还会扰乱翼片形状，改变细胞分裂的优先方向。我们的观察结果提供了证据，即相邻细胞之间残翅基因表达差异引发的局部细胞相互作用赋予了在控制翅膀生长和形状中起作用的位置值。
相似文献
1
Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster.果蝇翅膀中渐次变化的痕迹器官表达模式对生长和位置信息的控制。
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13734-9. doi: 10.1073/pnas.0606092103. Epub 2006 Sep 1.
2
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern.动态细胞募集过程通过过度扩大 vestigial 表达模式来驱动果蝇翅膀的生长。
Dev Biol. 2020 Jun 15;462(2):141-151. doi: 10.1016/j.ydbio.2020.03.009. Epub 2020 Mar 19.
3
The effect of dominant vestigial alleles upon vestigial-mediated wing patterning during development of Drosophila melanogaster.显性残翅等位基因对黑腹果蝇发育过程中残翅介导的翅型形成的影响。
Mech Dev. 1997 Sep;67(1):17-33. doi: 10.1016/s0925-4773(97)00096-8.
4
Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge.扇贝蛋白和痕迹蛋白在调节细胞亲和力以及翅片与翅铰链之间相互作用中的作用。
Dev Biol. 2000 Dec 15;228(2):287-303. doi: 10.1006/dbio.2000.9939.
5
Genetic requirements of vestigial in the regulation of Drosophila wing development.果蝇翅发育调控中残翅基因的遗传需求
Development. 2003 Jan;130(1):197-208. doi: 10.1242/dev.00187.
6
Regulation of Wingless and Vestigial expression in wing and haltere discs of Drosophila.果蝇翅和平衡棒盘中无翅基因（Wingless）和痕迹基因（Vestigial）表达的调控
Development. 2003 Apr;130(8):1537-47. doi: 10.1242/dev.00393.
7
Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial.表皮生长因子受体途径通过对残翅基因的调控在果蝇翅膀生长和图案形成中的作用
Development. 1999 Feb;126(5):975-85. doi: 10.1242/dev.126.5.975.
8
Restricted patterning of vestigial expression in Drosophila wing imaginal discs requires synergistic activation by both Mad and the drifter POU domain transcription factor.果蝇翅成虫盘vestigial基因表达的受限模式需要Mad和漂流者POU结构域转录因子的协同激活。
Development. 2000 Jul;127(14):3173-83. doi: 10.1242/dev.127.14.3173.
9
Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control.Wingless 信号时空调节的 Vestigial 梯度，自适应地调节细胞分裂，以精确控制翅膀大小。
J Theor Biol. 2011 Jan 7;268(1):131-40. doi: 10.1016/j.jtbi.2010.09.043.
10
Wingless promotes cell survival but constrains growth during Drosophila wing development.无翅基因在果蝇翅膀发育过程中促进细胞存活，但限制生长。
Nat Cell Biol. 2003 Sep;5(9):827-33. doi: 10.1038/ncb1041. Epub 2003 Aug 24.
引用本文的文献
1
Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.异常分化细胞克隆的消除与界面肌球蛋白 II 积累无关。
J Cell Sci. 2023 Jul 1;136(13). doi: 10.1242/jcs.259935. Epub 2023 Jul 11.
2
Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila.残迹依赖性诱导有助于稳健的模式形成，但对于果蝇翅膀命运的募集并非必不可少。
Biol Open. 2023 May 15;12(5). doi: 10.1242/bio.059908. Epub 2023 May 18.
3
Coupling cell proliferation rates to the duration of recruitment controls final size of the wing.细胞增殖率与募集持续时间的偶联控制着翅膀的最终大小。
Proc Biol Sci. 2022 Oct 12;289(1984):20221167. doi: 10.1098/rspb.2022.1167.
4
Elucidate growth control mechanisms using reconstructed spatiotemporal distributions of signaling events.利用信号事件的重建时空分布阐明生长控制机制。
Comput Struct Biotechnol J. 2021 Jun 18;19:3618-3627. doi: 10.1016/j.csbj.2021.06.019. eCollection 2021.
5
Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers.残迹基因介导胰岛素信号通路对叶蝉翅型转变的影响。
PLoS Genet. 2021 Feb 9;17(2):e1009312. doi: 10.1371/journal.pgen.1009312. eCollection 2021 Feb.
6
Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells.果蝇 headcase 基因的系统和局部效应及其在成体祖细胞应激保护中的作用。
PLoS Genet. 2021 Feb 8;17(2):e1009362. doi: 10.1371/journal.pgen.1009362. eCollection 2021 Feb.
7
Cell elimination strategies upon identity switch via modulation of apterous in Drosophila wing disc.通过调节果蝇翅盘中的无翅基因实现身份转换后的细胞消除策略。
PLoS Genet. 2019 Dec 26;15(12):e1008573. doi: 10.1371/journal.pgen.1008573. eCollection 2019 Dec.
8
ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila.ADAMTS Sol narae 裂解细胞外 Wingless 以产生一种新的活性形式，从而调节果蝇中的细胞增殖。
Cell Death Dis. 2019 Jul 22;10(8):564. doi: 10.1038/s41419-019-1794-8.
9
An ADAMTS Sol narae is required for cell survival in Drosophila.ADAMTS Sol narae 是果蝇细胞存活所必需的。
Sci Rep. 2019 Feb 4;9(1):1270. doi: 10.1038/s41598-018-37557-9.
10
How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects.你对自己的突变了解多少？遗传背景对表现度、互补作用及等位基因效应排序的复杂影响。
PLoS Genet. 2017 Nov 22;13(11):e1007075. doi: 10.1371/journal.pgen.1007075. eCollection 2017 Nov.
本文引用的文献
1
Regulation of cell proliferation by a morphogen gradient.形态发生素梯度对细胞增殖的调控。
Cell. 2005 Nov 4;123(3):449-61. doi: 10.1016/j.cell.2005.08.030.
2
The orientation of cell divisions determines the shape of Drosophila organs.细胞分裂的方向决定了果蝇器官的形状。
Curr Biol. 2005 Sep 20;15(18):1640-4. doi: 10.1016/j.cub.2005.07.062.
3
Drosophila genetic variants that change cell size and rate of proliferation affect cell communication and hence patterning.改变细胞大小和增殖速率的果蝇遗传变异会影响细胞通讯，进而影响模式形成。
Mech Dev. 2004 Apr;121(4):351-64. doi: 10.1016/j.mod.2004.02.007.
4
Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing.细胞周期蛋白依赖性激酶对dE2F1的负调控控制细胞周期时间。
Cell. 2004 Apr 16;117(2):253-64. doi: 10.1016/s0092-8674(04)00247-8.
5
Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway.果蝇翅片上spalt基因表达受Decapentaplegic信号通路调控。
Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6021-6. doi: 10.1073/pnas.0401590101. Epub 2004 Apr 12.
6
Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin.无翅蛋白对dMyc表达的抑制促进了Rbf诱导的果蝇翅前缘G1期阻滞。
Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3857-62. doi: 10.1073/pnas.0400526101. Epub 2004 Mar 4.
7
Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.无翅和Notch信号通路在翅膀发育过程中提供细胞存活信号并控制细胞增殖。
Development. 2003 Dec;130(26):6533-43. doi: 10.1242/dev.00904.
8
The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc.果蝇翅膀分化因子“痕迹-扇形”是翅成虫盘背腹边界处细胞增殖和细胞存活所必需的。
Cell Death Differ. 2004 Jan;11(1):110-22. doi: 10.1038/sj.cdd.4401321.
9
Wingless promotes cell survival but constrains growth during Drosophila wing development.无翅基因在果蝇翅膀发育过程中促进细胞存活，但限制生长。
Nat Cell Biol. 2003 Sep;5(9):827-33. doi: 10.1038/ncb1041. Epub 2003 Aug 24.
10
Defective proventriculus is required for pattern formation along the proximodistal axis, cell proliferation and formation of veins in the Drosophila wing.果蝇翅膀沿近端到远端轴的模式形成、细胞增殖和翅脉形成需要有缺陷的前胃。
Development. 2003 Sep;130(17):4135-47. doi: 10.1242/dev.00608.
Zotero 插件