Ro J Y, Sahin A A, Ayala A G, Ordonez N G, Grignon D J, Popok S M
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Cancer. 1990 Jul 15;66(2):347-53. doi: 10.1002/1097-0142(19900715)66:2<347::aid-cncr2820660224>3.0.co;2-i.
Tumor-to-tumor metastases are uncommon. The most frequent donor tumors are the lung, whereas renal cell carcinoma is by far the most common recipient. In this report the authors describe a lung tumor that metastasized to a testicular seminoma. This is the first reported case of tumor-to-tumor metastases in which seminoma of the testis is the recipient. The authors performed mucin and immunohistochemical studies on this case and on ten cases of nonseminomatous germ cell tumors containing embryonal carcinoma and endodermal sinus tumor for comparison. Mucin positivity as well as immunoreactivity for epithelial membrane and carcinoembryonic antigens were confined to metastatic adenocarcinoma in this case, whereas Ki-1 and alpha-fetoprotein immunostaining were restricted to the ten control cases of germ cell tumors. Although the majority of second malignant components found in a seminoma are other nonseminomatous germ cell components, the rare possibility exists that a second malignant component is a metastasis from elsewhere in the body.
肿瘤转移至肿瘤的情况并不常见。最常见的原发肿瘤是肺癌，而肾细胞癌是迄今为止最常见的继发肿瘤。在本报告中，作者描述了一例转移至睾丸精原细胞瘤的肺肿瘤。这是首例报告的以睾丸精原细胞瘤作为继发肿瘤的肿瘤转移至肿瘤病例。作者对该病例以及十例包含胚胎癌和内胚窦瘤的非精原细胞性生殖细胞肿瘤病例进行了黏液和免疫组化研究以作比较。在该病例中，黏液阳性以及上皮膜抗原和癌胚抗原的免疫反应性仅限于转移性腺癌，而Ki-1和甲胎蛋白免疫染色则仅限于十例生殖细胞肿瘤对照病例。虽然在精原细胞瘤中发现的大多数第二恶性成分是其他非精原细胞性生殖细胞成分，但仍存在第二恶性成分是身体其他部位转移灶的罕见可能性。
