Bury Yvonne, Green Richard, Jain Mona, Moor James
Cellular Pathology Department, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
BMJ Case Rep. 2012 Apr 4;2012:bcr0120125517. doi: 10.1136/bcr.01.2012.5517.
Tumour-to-tumour metastasis is a rare phenomenon, but has been described in the literature in just over 100 cases. It can be particularly puzzling for the reporting pathologists, when encountered unexpectedly in a tumour showing abrupt transition from the usual morphology to another unusual pattern. The literature reports a variety of combinations with carcinoma-to-carcinoma being the most common; and renal cell carcinomas appear to the most common recipient tumours with common donor tumours being breast, lung and renal cell carcinomas. The authors report a case of poorly-differentiated lung carcinoma metastasising into a carotid body paraganglioma. Our case is unique and in our knowledge the first described case of carotid body paraganglioma with metastasis from a lung primary. To the best of our knowledge this is the first report of this interesting biological phenomenon in this combination.
肿瘤转移至肿瘤是一种罕见现象，但文献中已报道了100多例。当在肿瘤中意外遇到肿瘤形态突然从常见形态转变为另一种不寻常模式时，这对报告病理学家来说可能特别令人困惑。文献报道了多种组合，其中癌转移至癌最为常见；肾细胞癌似乎是最常见的受体肿瘤，常见的供体肿瘤是乳腺癌、肺癌和肾细胞癌。作者报告了一例低分化肺癌转移至颈动脉体副神经节瘤的病例。我们的病例很独特，据我们所知，这是首例描述的原发性肺癌转移至颈动脉体副神经节瘤的病例。据我们所知，这是这种有趣的生物学现象在这种组合中的首次报告。
