Hawgood Barbara J
26 Cloister Road, Acton, London W3 0DE, UK.
Toxicon. 2006 Dec 1;48(7):768-79. doi: 10.1016/j.toxicon.2006.07.014. Epub 2006 Jul 14.
Bob Endean was a dedicated marine biologist with an extensive knowledge of coral reef communities in the Great Barrier Reef and fauna in subtropical Queensland waters. He commenced a study of venomous and poisonous marine animals dangerous to man at a time when the field was new, employing a variety of techniques to investigate the venom apparatus, mode of delivery of venom or toxin, mode of toxic action on excitable tissues, and biochemistry of venom or toxin. Determination of the pharmacological properties of crude venom from Conus marine snails advanced characterization of conotoxins by later workers. A study of four types of nematocysts from the box-jellyfish Chironex fleckeri provided information as to their structure, function, and mechanism of discharge; myotoxins T1 and T2 were isolated from microbasic mastigophores. Endean studied poisonous stonefish (Synanceia trachynis) and, with Ann Cameron, scorpionfish (Notesthes robusta); investigations of ciguatera and of paralytic shellfish poisoning were initiated. He organized the collection of Australian frogs which led to the isolation of caerulein by Erspamer in Italy. Endean highlighted the ecological danger of the population explosion of the crown-of-thorns starfish (Acanthaster planci) and provided the impetus for the creation of the Great Barrier Reef Marine Park.
鲍勃·恩迪安是一位专注的海洋生物学家，对大堡礁的珊瑚礁群落以及亚热带昆士兰水域的动物有着广泛的了解。在该领域尚属新兴阶段时，他就开始了对人类有害的有毒海洋动物的研究，运用多种技术来探究毒液器官、毒液或毒素的输送方式、对可兴奋组织的毒性作用方式以及毒液或毒素的生物化学性质。对芋螺属海洋蜗牛粗毒液药理特性的测定推动了后来研究人员对芋螺毒素的进一步表征。对箱形水母“ Chironex fleckeri”的四种刺丝囊的研究提供了有关其结构、功能和排放机制的信息；从微基部鞭毛体中分离出了肌毒素T1和T2。恩迪安研究了有毒的石鱼（“ Synanceia trachynis”），并与安·卡梅隆一起研究了鲉鱼（“ Notesthes robusta”）；启动了对雪卡毒素和麻痹性贝类中毒的调查。他组织了澳大利亚青蛙的采集工作，这使得意大利的埃斯帕默分离出了蛙皮素。恩迪安强调了棘冠海星（“ Acanthaster planci”）种群爆炸带来的生态危险，并为大堡礁海洋公园的创建提供了动力。
