Prevost J, Orr T W, Pearson G R
Proc Natl Acad Sci U S A. 1975 May;72(5):1671-5. doi: 10.1073/pnas.72.5.1671.
Sera from owl monkeys infected with Herpesvirus saimiri (HVS) mediated antibody-dependent lymphocyte cytotoxicity (ADLC) against virus-infected owl monkey kidney cells. Peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. ADLC titers increased along with membrane immunofluorescence (MF) titers but among some sera, the ADLC titers were much higher than expected from the MF titers, suggesting that multiple serum factors were involved in mediating ADLC in this system. Absorption of both low and high titered sera with HVS-infected owl monkey kidney cells removed all ADLC activity. Preliminary results from serial serum samples from two infected monkeys that developed leukemia and/or lymphoma demonstrated that ADLC but not MF titers increased to high titers with progression of disease and followed essentially a different kinetic pattern than that noted by MF. The possible significance of these findings in relation to malignant disease induced by this virus is discussed.
感染了猴疱疹病毒（HVS）的夜猴血清介导了针对病毒感染的夜猴肾细胞的抗体依赖性淋巴细胞细胞毒性（ADLC）。恒河猴的外周血淋巴细胞在该细胞毒性试验中用作效应细胞。ADLC滴度随膜免疫荧光（MF）滴度升高而升高，但在一些血清中，ADLC滴度远高于MF滴度预期值，这表明该系统中多种血清因子参与介导ADLC。用HVS感染的夜猴肾细胞吸收低滴度和高滴度血清均可消除所有ADLC活性。来自两只患白血病和/或淋巴瘤的感染猴的系列血清样本的初步结果表明，随着疾病进展，ADLC滴度而非MF滴度升高至高滴度，且其动力学模式与MF基本不同。讨论了这些发现与该病毒诱发恶性疾病的可能相关性。
