Bavbek Sevim, Erkekol Ferda Oner, Ceter Talip, Mungan Dilşad, Ozer Faruk, Pinar Münevver, Misirligil Zeynep
Department of Allergic Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey.
J Asthma. 2006 Aug;43(6):421-6. doi: 10.1080/02770900600710706.
Sensitization to Alternaria and Cladosporium has been reported to be 3% to 30% in European countries. However, in Turkey, there is limited data about the prevalence of sensitization to these molds and the intensity of the two mold spores in Ankara atmosphere. This study was designed to evaluate the sensitization to Alternaria and Cladosporium in patients with respiratory allergy in Ankara and also the concentration of the two molds in Ankara atmosphere. Allergic rhinitis and asthma patients living in Ankara were included in the study. Demographic and diagnostic data of the patients were recorded. A skin prick test with extracts supplied by three different laboratories was used to evaluate the sensitization to Alternaria and Cladosporium. Mold spores were measured using a Burkard 7-day recording volumetric spore trap in Ankara atmosphere during a year. Overall sensitization to the two molds was found to be 14.8%, and isolated Alternaria or Cladosporiumsensitization was 3%. Considering the positive reaction to at least one of the three suppliers, the sensitization rate was 11.9% and 8.1% for Alternaria and Cladosporium, respectively. Cochran's Q homogenization test demonstrated that the positive and negative reaction were not homogeneous among three laboratories. The total number of mold spores in Ankara atmosphere was 429,264 spores/m3 of which 75.5% and 6% were constituted by Cladosporium and Alternaria, respectively. The prevalence of Cladosporium and Alternaria sensitization in respiratory allergy patients is quite similar to European countries; however, our data indicate that commercial mold extracts should be standardized to establish the real sensitization rates. Additionally, considering the great numbers of these mold spores in Ankara atmosphere, long-term follow-up studies are needed to evaluate the relationship between the mold load and sensitization patterns.
据报道，在欧洲国家，对链格孢属和枝孢属的致敏率为3%至30%。然而，在土耳其，关于安卡拉地区对这些霉菌的致敏率以及这两种霉菌孢子在大气中的浓度的数据有限。本研究旨在评估安卡拉地区呼吸过敏患者对链格孢属和枝孢属的致敏情况，以及这两种霉菌在安卡拉大气中的浓度。居住在安卡拉的过敏性鼻炎和哮喘患者被纳入研究。记录患者的人口统计学和诊断数据。使用由三个不同实验室提供的提取物进行皮肤点刺试验，以评估对链格孢属和枝孢属的致敏情况。在安卡拉地区，使用伯卡德7天记录式容积孢子捕捉器对霉菌孢子进行了为期一年的测量。发现对这两种霉菌的总体致敏率为14.8%，单独对链格孢属或枝孢属的致敏率为3%。考虑到对三个供应商中至少一个的阳性反应，链格孢属和枝孢属的致敏率分别为11.9%和8.1%。 Cochr an Q一致性检验表明，三个实验室之间的阳性和阴性反应不一致。安卡拉大气中霉菌孢子的总数为429,264个孢子/立方米，其中枝孢属和链格孢属分别占75.5%和6%。呼吸过敏患者中枝孢属和链格孢属致敏的患病率与欧洲国家相当；然而，我们的数据表明，商业霉菌提取物应进行标准化，以确定实际的致敏率。此外，考虑到安卡拉大气中这些霉菌孢子的数量众多，需要进行长期随访研究，以评估霉菌负荷与致敏模式之间的关系。
