Baibergenova Akerke, Thabane Lehana, Akhtar-Danesh Noori, Levine Mitchell, Gafni Amiram
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
J Asthma. 2006 Aug;43(6):469-75. doi: 10.1080/02770900600758382.
To identify patient characteristics associated with nocturnal emergency department (ED) visits for asthma.
Asthmatic patients 18 to 55 years of age who visited Ontario EDs between April 1, 2003 and March 31, 2004, were identified through an administrative clinical database. Patients' time of ED presentation was analyzed for circadian pattern using histogram and polynomial regression. Risk of nocturnal visit (presentation at the ED between midnight and 8 AM) was modeled through generalized estimating equations with patient age, gender, and asthma severity level as covariates. The effect of nocturnal visit on return rate to the ED within 14 days after the initial visit was determined through Cox regression.
During study period there were 31,490 ED visits for asthma made by 23,253 patients. Their time of ED visits displayed a distinct circadian pattern with peak between 7 and 8 PM, and trough at 5 AM. Approximately 22% of visits (6,868) occurred at night. Men had higher odds of presenting at night than women (OR 1.61; 1.49-1.73). Patients with mild asthma were significantly less likely to visit the ED at night than patients with moderate or severe asthma. Nocturnal presentation was not associated with higher odds of subsequent returns to the ED (HR 1.00; 0.89-1.14).
Higher odds of nocturnal visits in men suggest the existence of gender-differences in health-seeking behavior in asthmatics. Although nocturnal visits are associated with more severe asthma, they do not lead to higher return rates.
确定与夜间哮喘急诊就诊相关的患者特征。
通过行政临床数据库识别出2003年4月1日至2004年3月31日期间前往安大略省急诊室就诊的18至55岁哮喘患者。使用直方图和多项式回归分析患者的急诊就诊时间,以确定昼夜节律模式。以患者年龄、性别和哮喘严重程度级别作为协变量,通过广义估计方程对夜间就诊(午夜至上午8点之间到急诊室就诊)的风险进行建模。通过Cox回归确定夜间就诊对首次就诊后14天内急诊室复诊率的影响。
在研究期间,23253名患者进行了31490次哮喘急诊就诊。他们的急诊就诊时间呈现出明显的昼夜节律模式,晚上7点至8点达到高峰,凌晨5点为低谷。约22%(6868次)的就诊发生在夜间。男性夜间就诊的几率高于女性(比值比1.61;1.49 - 1.73)。轻度哮喘患者夜间前往急诊室就诊的可能性明显低于中度或重度哮喘患者。夜间就诊与随后返回急诊室的较高几率无关(风险比1.00;0.89 - 1.14)。
男性夜间就诊几率较高表明哮喘患者在就医行为上存在性别差异。虽然夜间就诊与更严重的哮喘相关,但并不会导致更高的复诊率。