Baibergenova Akerke, Thabane Lehana, Akhtar-Danesh Noori, Levine Mitchell, Gafni Amiram
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
J Asthma. 2006 May;43(4):293-9. doi: 10.1080/02770900600622984.
To investigate if fetal gender (1) affects the risk of having an emergency department (ED) visit for asthma; and (2) is associated with adverse pregnancy outcomes among women who had at least one visit to the ED for asthma during pregnancy.
We linked two provincial administrative databases containing records on in-patient deliveries and ED visits. The study sample included women who delivered a live singleton baby between April 2003 and March 2004. Pregnant women who made at least one ED visit for asthma were counted as cases and the rest of the women as control subjects. We performed a multivariable analysis using logistic regression to model the risk of having an ED visit for asthma, with fetal gender being one of the predictors. In addition, a series of multivariable logistic regressions were also constructed separately for cases and controls for the following adverse delivery outcomes: low birth weight baby, preterm delivery, and delivery via Caesarian section.
Among 109,173 live singleton deliveries, 530 women had visited ED due to asthma during pregnancy. While having an ED visit for asthma was positively associated with teenage pregnancy, low income, and presence of pregnancy-induced hypertension, it was not associated with fetal gender (OR 1.01, 95% CI 0.85-1.19). Fetal gender was not a significant predictor of adverse pregnancy outcomes among women who had an asthma ED visit during pregnancy.
Fetal gender does not affect the risk of having an ED visit for asthma during pregnancy, and it is not associated with adverse pregnancy outcomes among women who had an asthma-related ED during pregnancy.
调查胎儿性别(1)是否会影响因哮喘前往急诊科就诊的风险;以及(2)是否与孕期因哮喘至少前往急诊科就诊一次的女性的不良妊娠结局相关。
我们将两个省级行政数据库相链接,其中包含住院分娩和急诊科就诊记录。研究样本包括2003年4月至2004年3月期间分娩单胎活婴的女性。因哮喘至少前往急诊科就诊一次的孕妇被计为病例,其余女性作为对照对象。我们使用逻辑回归进行多变量分析,以模拟因哮喘前往急诊科就诊的风险,胎儿性别为预测因素之一。此外,还分别针对病例组和对照组构建了一系列多变量逻辑回归,以分析以下不良分娩结局:低体重儿、早产和剖宫产。
在109,173例单胎活产中,530名女性在孕期因哮喘前往急诊科就诊。虽然因哮喘前往急诊科就诊与青少年妊娠、低收入和妊娠高血压的存在呈正相关,但与胎儿性别无关(比值比1.01,95%可信区间0.85 - 1.19)。胎儿性别并非孕期因哮喘前往急诊科就诊的女性不良妊娠结局的显著预测因素。
胎儿性别不影响孕期因哮喘前往急诊科就诊的风险,且与孕期因哮喘相关而前往急诊科就诊的女性的不良妊娠结局无关。