Dudko Olga K, Weiss George H, Chernomordik Victor
Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA.
Phys Med Biol. 2006 Sep 21;51(18):4719-33. doi: 10.1088/0031-9155/51/18/017. Epub 2006 Sep 4.
We study the effect of optical anisotropy on the mean time-of-flight of photons in a slab of turbid medium containing an inclusion whose optical properties differ from those of the bulk. For this analysis the difference in the mean time for a photon introduced into the slab to reach a specified target point with and without the inclusion is calculated. This difference is defined to be a measure of the contrast. The theoretical model is based on a continuous-time random walk on a lattice, which can be solved exactly and furnishes an exact expression for the contrast. Qualitative and quantitative characteristics of the contrast are analysed as functions of the geometric configuration of the system components (locations of the source, the inclusion and the detector), parameters that specify the optical anisotropy of the medium, and either the scattering properties of the inclusion or the lifetime of the small fluorophore in the case of the time-resolved fluorescence experimental configuration.
我们研究了光学各向异性对光子在含有光学性质与主体不同的内含物的浑浊介质平板中的平均飞行时间的影响。对于此分析，计算了在有和没有内含物的情况下，引入平板中的光子到达指定目标点的平均时间之差。该差值被定义为对比度的一种度量。理论模型基于晶格上的连续时间随机游走，它可以精确求解并给出对比度的精确表达式。作为系统组件的几何配置（源、内含物和探测器的位置）、指定介质光学各向异性的参数以及内含物的散射特性或时间分辨荧光实验配置情况下小荧光团的寿命的函数，分析了对比度的定性和定量特征。
