Hebden J C, Arridge S R
Appl Opt. 1996 Dec 1;35(34):6788-96. doi: 10.1364/AO.35.006788.
A method of generating images through highly scattering media is presented that involves comparing measurements of the time-dependent intensity of transmitted light with an analytical model describing the sensitivity of that intensity on localized changes in optical properties. A least-squares fitting procedure is employed to derive the amplitudes of the measurement perturbations caused by embedded absorbers and scatterers located along a line of sight between the source and detector. Images are presented of a highly scattering, solid plastic phantom with optical properties closely matched to those of human breast tissue at near-infrared wavelengths. The phantom is a 54-mm-thick slab, containing four small cylinders of contrasting scatter and absorption. Results show that embedded absorbers can be distinguished from embedded scatterers, and that the diffusion perturbation amplitude provides inherently greater spatial resolution than the absorption perturbation amplitude.
提出了一种通过高散射介质生成图像的方法，该方法涉及将透射光随时间变化的强度测量值与描述该强度对光学特性局部变化敏感度的分析模型进行比较。采用最小二乘拟合程序来推导由沿源与探测器之间视线路径上的嵌入式吸收体和散射体引起的测量扰动幅度。展示了一个高散射的固体塑料模型的图像，其光学特性在近红外波长下与人类乳腺组织的光学特性紧密匹配。该模型是一个54毫米厚的平板，包含四个具有不同散射和吸收特性的小圆柱体。结果表明，嵌入式吸收体可以与嵌入式散射体区分开来，并且扩散扰动幅度比吸收扰动幅度具有更高的固有空间分辨率。
