Aizawa S, Sako K, Yonemasu Y
Department of Neurosurgery, Asahikawa Medical College, Hokkaido.
Neurol Med Chir (Tokyo). 1990 Feb;30(2):113-8. doi: 10.2176/nmc.30.113.
Effective chemotherapy and radiation therapy of brain tumors require knowledge of the cerebral circulatory dynamics involved. In this study, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), and regional cerebral capillary permeability (rCP) were measured in Wistar King Aptekman rats bearing experimental KEG-1 gliomas. These parameters were assessed by autoradiography with 14C-iodoantipyrine, 14C-deoxyglucose-labeled red blood cells, and 14C-aminoisobutyric acid, respectively. rCBF within the tumor was approximately one third that in the contralateral cortex and was consistently higher in the periphery than in the center of the tumor. In the periphery of the tumor, rCBV was approximately twice that in the contralateral cortex, but it was very low in the center of the tumor. Throughout the tumor, rCP was sharply increased relative to that measured in the contralateral cortex, and the increase was especially pronounced in the central portion. Thus, rCBF, rCBV, and rCP each appeared to vary within the tumor, implying that the combined use of lipid- and water-soluble chemotherapeutic agents is reasonable. Measurement of these parameters may also provide indices of radiation sensitivity.
脑肿瘤的有效化疗和放射治疗需要了解其中涉及的脑循环动力学。在本研究中，对携带实验性KEG - 1胶质瘤的Wistar King Aptekman大鼠测量了局部脑血流量（rCBF）、局部脑血容量（rCBV）和局部脑毛细血管通透性（rCP）。这些参数分别通过用¹⁴C - 碘安替比林、¹⁴C - 脱氧葡萄糖标记的红细胞和¹⁴C - 氨基异丁酸进行放射自显影来评估。肿瘤内的rCBF约为对侧皮质的三分之一，且在肿瘤周边始终高于肿瘤中心。在肿瘤周边，rCBV约为对侧皮质的两倍，但在肿瘤中心非常低。在整个肿瘤中，rCP相对于对侧皮质测量值急剧增加，且在中央部分增加尤为明显。因此，rCBF、rCBV和rCP在肿瘤内似乎各自有所不同，这意味着联合使用脂溶性和水溶性化疗药物是合理的。测量这些参数也可能提供放射敏感性指标。
