Suzuki N, Sako K, Yonemasu Y
Department of Neurosurgery, Asahikawa Medical College, Japan.
J Neurooncol. 1991 Jun;10(3):213-8. doi: 10.1007/BF00177533.
To study the possibility of enhancing the delivery of antineoplastic agents to tumor tissue, we conducted an experimental study using induced hypertension with angiotensin II in rats with experimental brain tumors. Drug delivery was evaluated by measuring local cerebral blood flow (LCBF) and regional cerebral capillary permeability with quantitative autoradiography. There was no significant difference of LCBF in the central region of tumor tissue between the control group and the induced hypertension group. LCBF in the peripheral region of tumor tissue in the induced hypertension group was significantly higher than that in the control group. On the other hand, despite induced hypertension, no significant changes in the regional cerebral capillary permeability were observed between the groups. These results indicate that delivery of the lipid-soluble antineoplastic agents, which depend upon cerebral blood flow, can be enhanced by induced hypertension.
为研究增强抗肿瘤药物向肿瘤组织递送的可能性，我们在患有实验性脑肿瘤的大鼠中使用血管紧张素II诱导高血压进行了一项实验研究。通过定量放射自显影测量局部脑血流量（LCBF）和局部脑毛细血管通透性来评估药物递送情况。对照组和诱导高血压组之间肿瘤组织中央区域的LCBF无显著差异。诱导高血压组肿瘤组织周边区域的LCBF显著高于对照组。另一方面，尽管诱导了高血压，但两组之间局部脑毛细血管通透性未观察到显著变化。这些结果表明，依赖脑血流量的脂溶性抗肿瘤药物的递送可通过诱导高血压来增强。
