Kanoni Stavroula, Dedoussis George, Manios Yannis, Malavolta Marco, Mocchegiani Eugenio
Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou str, 17671 , Kallithea-Athens, Greece.
Biogerontology. 2006 Oct-Dec;7(5-6):329-37. doi: 10.1007/s10522-006-9047-5.
As the elderly population is increasing rapidly, there is a lot of scientific interest in clarifying the differential life-style, genetic, biochemical and molecular factors contributing to mortality or exceptional longevity. Within the framework of the ZINCAGE project, 249 old (60-85 years) and nonagenarian Greek subjects (>/=85 years old) were recruited and anthropometrical, blood and biochemical indices as well as blood pressure measurements were obtained. Based upon the inclusion criteria, 214 of them were characterized as healthy (136 female, 78 male), while those characterized as non-healthy were excluded from the statistical analysis. The findings indicated an 88.4% prevalence of overweight and obesity in elderly (91.2% in women, 83.3% in men), while a significant decrease in body mass index with age was recorded. Hypercholesterolemia was observed in 75.3% of elderly women and in 69.2% of men. Erythrocyte sedimentation rate value was increased in 27.6% of all healthy elderly, while zinc deficiency was observed in 18.7% of elderly. Over 85.0% of all healthy elderly were within normal range for all other hematological analysis. Blood analysis confirmed the good health status of the elderly recruited as healthy, except for the high prevalence of obesity and hypercholesterolemia.
随着老年人口的迅速增加,人们对阐明导致死亡或超长寿命的不同生活方式、遗传、生化和分子因素产生了浓厚的科学兴趣。在ZINCAGE项目的框架内,招募了249名年龄在60 - 85岁的老年人和百岁老人(≥85岁)的希腊受试者,并获取了人体测量、血液和生化指标以及血压测量值。根据纳入标准,其中214人被判定为健康(女性136人,男性78人),而那些被判定为不健康的人被排除在统计分析之外。研究结果表明,老年人中超重和肥胖的患病率为88.4%(女性为91.2%,男性为83.3%),同时记录到体重指数随年龄显著下降。75.3%的老年女性和69.2%的老年男性存在高胆固醇血症。在所有健康老年人中,27.6%的人红细胞沉降率值升高,18.7%的老年人存在锌缺乏。在所有健康老年人中,超过85.0%的人在所有其他血液学分析中处于正常范围。血液分析证实了被招募为健康的老年人的良好健康状况,但肥胖和高胆固醇血症的患病率较高。