Carlsson M, Carlsson A
Department of Pharmacology, University of Göteborg, Sweden.
Trends Neurosci. 1990 Jul;13(7):272-6. doi: 10.1016/0166-2236(90)90108-m.
Recent animal experiments suggest that dopamine plays a less crucial role than formerly supposed in the regulation of psychomotor functions. This is illustrated by the finding that even in the almost complete absence of brain dopamine, a pronounced behavioural activation is produced in mice following suppression of glutamatergic neurotransmission. This paper discusses the possibility that a deficient activity within the corticostriatal glutamatergic/aspartergic pathway may be an important pathophysiological component in schizophrenia, and that glutamatergic agonists may be beneficial in the treatment of this disease. In addition, it is suggested that glutamatergic antagonists may be valuable supplements in the treatment of Parkinson's disease.
最近的动物实验表明，多巴胺在精神运动功能调节中所起的作用比以前认为的要小。这一点体现在以下发现中：即使在大脑多巴胺几乎完全缺失的情况下，抑制谷氨酸能神经传递后，小鼠仍会产生明显的行为激活。本文讨论了皮质纹状体谷氨酸能/天冬氨酸能通路内活性不足可能是精神分裂症重要病理生理组成部分的可能性，以及谷氨酸能激动剂可能对该病治疗有益的观点。此外，有人提出谷氨酸能拮抗剂可能是帕金森病治疗中有价值的补充药物。
