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以色列家禽群体中传播的H9N2流感病毒的基因特征分析。

Genetic characterization of the H9N2 influenza viruses circulated in the poultry population in Israel.

作者信息

Perk Shimon, Banet-Noach Caroline, Shihmanter Ester, Pokamunski Shimon, Pirak Michael, Lipkind Michael, Panshin Alexander

机构信息

Division of Avian and Aquatic Animals Diseases, Kimron Veterinary Institute, Beit Dagan, ZC 50250, Israel.

出版信息

Comp Immunol Microbiol Infect Dis. 2006 Jul;29(4):207-23. doi: 10.1016/j.cimid.2006.06.004. Epub 2006 Sep 6.

DOI:10.1016/j.cimid.2006.06.004
PMID:16954048
Abstract

The partial nucleotide sequences of the hemagglutinin (HA) genes of 72 H9N2 influenza viruses isolated from chickens and turkeys in Israel during the period 2000-2005 were genetically analyzed. The isolates possessed the three types of amino acid motif -R-S-S-R/G-L-, -R-S-N-R/G-L-, and -R-S-K-R/G-L- at the cleavage site of HA. Phylogenetic analyses showed that all Israeli isolates belonged to the same group which further divided into three closely related sub-groups. The HA genes of these isolates were related to the HA gene of A/chicken/Germany/R45/98 isolated from chicken in Germany in 1998.

摘要

对2000年至2005年期间从以色列鸡和火鸡中分离出的72株H9N2流感病毒的血凝素(HA)基因的部分核苷酸序列进行了遗传分析。这些分离株在HA裂解位点具有三种氨基酸基序——-R-S-S-R/G-L-、-R-S-N-R/G-L-和-R-S-K-R/G-L-。系统发育分析表明,所有以色列分离株属于同一组,该组进一步分为三个密切相关的亚组。这些分离株的HA基因与1998年从德国鸡中分离出的A/鸡/德国/R45/98的HA基因相关。

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