利用人类淋巴细胞中的染色体畸变进行生物剂量测定。
Biodosimetry using chromosome aberrations in human lymphocytes.
作者信息
Senthamizhchelvan S, Pant G S, Rath G K, Julka P K, Nair O, Joshi R C, Malhotra A, Pandey R M
机构信息
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India.
出版信息
Radiat Prot Dosimetry. 2007;123(2):241-5. doi: 10.1093/rpd/ncl109. Epub 2006 Sep 5.
In vitro dose-response calibration curves for (60)Co gamma rays have been established for unstable chromosome aberrations in human peripheral blood lymphocytes. The observed dose-response data were fitted to a linear quadratic model. The calibration curve parameters were used to estimate the equivalent whole-body dose and dose to the irradiated region in partial body irradiation of cancer patients. The derived partial body doses and fractions of lymphocytes irradiated were in agreement with those estimated from the radiotherapy regimes.
已针对人类外周血淋巴细胞中的不稳定染色体畸变建立了（60）Coγ射线的体外剂量反应校准曲线。将观察到的剂量反应数据拟合到线性二次模型。校准曲线参数用于估计癌症患者局部身体照射时的全身等效剂量和受照射区域的剂量。得出的局部身体剂量和受照射淋巴细胞的比例与从放射治疗方案估计的结果一致。
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