酸阻断对小鼠胃组胺的影响。
Effect of acid blockade on gastric histamine in mice.
作者信息
Man W K, Gompertz R H, Michalowski A S, Li S K, Baron J H, Spencer J
机构信息
Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Agents Actions. 1990 Apr;30(1-2):182-4. doi: 10.1007/BF01969032.
Vagotomy and omeprazole effectively inhibited 2-deoxy-D-glucose (-91%) and pentagastrin (-72%) stimulated acid production in mice, respectively. Both vagotomy and omeprazole treatment were accompanied by massive increases in histamine secretion (8-fold or more, during both basal and stimulated states). Mucosal stores of histamine, however, were not depleted. Similar rises in luminal histamine have been observed in patients treated in these ways. The mouse model may thus be suitable to elucidate the kinetics of histamine release in patients.
迷走神经切断术和奥美拉唑分别有效抑制了小鼠中2-脱氧-D-葡萄糖（-91%）和五肽胃泌素（-72%）刺激的胃酸分泌。迷走神经切断术和奥美拉唑治疗均伴随着组胺分泌的大量增加（在基础状态和刺激状态下均增加8倍或更多）。然而，组胺的黏膜储存并未耗尽。以这些方式治疗的患者也观察到了管腔内组胺的类似升高。因此，该小鼠模型可能适合阐明患者体内组胺释放的动力学。
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