组胺与十二指肠溃疡：奥美拉唑对十二指肠溃疡患者胃组胺的影响
Histamine and duodenal ulcer: effect of omeprazole on gastric histamine in patients with duodenal ulcer.
作者信息
Man W K, Thompson J N, Baron J H, Spencer J
出版信息
Gut. 1986 Apr;27(4):418-22. doi: 10.1136/gut.27.4.418.
Gastric mucosal concentrations of histamine and of its metabolic enzyme, histamine methyltransferase activity, were measured in patients with duodenal ulcer disease and patients with an apparently normal stomach and duodenum. Patients with duodenal ulcer had significantly less (p less than 0.05) mucosal histamine (median 204 nmol/g) than control subjects (median 252 nmol/g). There was no significant difference between the two groups in their histamine methyltransferase activity values. Omeprazole therapy did not significantly change mucosal histamine (+23%), histamine methyltransferase activity (+5%), histamine release before (+5%) or during (+7%) pentagastrin infusion. It significantly decreased acid secretion during pentagastrin stimulation (median -73%, p less than 0.001). Omeprazole, like cimetidine, does not stop histamine release during pentagastrin stimulation.
在十二指肠溃疡患者以及胃和十二指肠看似正常的患者中，测量了胃黏膜中组胺及其代谢酶——组胺甲基转移酶活性的浓度。十二指肠溃疡患者的黏膜组胺（中位数204纳摩尔/克）明显低于对照组（中位数252纳摩尔/克）（p<0.05）。两组的组胺甲基转移酶活性值无显著差异。奥美拉唑治疗并未显著改变黏膜组胺（增加23%）、组胺甲基转移酶活性（增加5%）、五肽胃泌素输注前（增加5%）或输注期间（增加7%）的组胺释放。它显著降低了五肽胃泌素刺激期间的胃酸分泌（中位数 -73%，p<0.001）。与西咪替丁一样，奥美拉唑不会阻止五肽胃泌素刺激期间的组胺释放。
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