Lee P Y, Pearce F L
Department of Chemistry, University College London, UK.
Agents Actions. 1990 Apr;30(1-2):67-9. doi: 10.1007/BF01969000.
Bradykinin and a range of peptide analogues induced a dose-dependent release of histamine from rat peritoneal mast cells. The characteristics of the release were not consistent with the involvement of defined bradykinin receptors but indicated that the peptide acted through the putative mast cell polyamine receptor. Consistently, the effect of bradykinin was largely confined to serosal mast cells of the rat and hamster, while human histaminocytes were essentially unresponsive. These data do then not support a general role for kinin-induced activation of mast cells in human allergic disease.
缓激肽及一系列肽类似物可诱导大鼠腹膜肥大细胞组胺呈剂量依赖性释放。释放的特征与特定缓激肽受体的参与不一致，但表明该肽通过假定的肥大细胞多胺受体起作用。一致的是，缓激肽的作用主要局限于大鼠和仓鼠的浆膜肥大细胞，而人组胺细胞基本无反应。因此，这些数据不支持激肽诱导的肥大细胞活化在人类过敏性疾病中的普遍作用。
