颅内出血：继发性脑损伤的机制
Intracranial hemorrhage: mechanisms of secondary brain injury.
作者信息
Lok Josephine, Leung Wendy, Murphy Sarah, Butler William, Noviski Natan, Lo Eng H
机构信息
Neuroprotection Research Laboratory, Department of Pediatrics, Pediatric Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Acta Neurochir Suppl. 2011;111:63-9. doi: 10.1007/978-3-7091-0693-8_11.
Abstract
ICH is a disease with high rates of mortality and morbidity, with a substantial public health impact. Spontaneous ICH (sICH) has been extensively studied, and a large body of data has been accumulated on its pathophysiology. However, the literature on traumatic ICH (tICH) is limited, and further investigations of this important topic are needed. This review will highlight some of the cellular pathways in ICH with an emphasis on the mechanisms of secondary injury due to heme toxicity and to events in the coagulation process that are common to both sICH and tICH.
摘要
脑出血是一种死亡率和发病率都很高的疾病，对公众健康有重大影响。自发性脑出血（sICH）已得到广泛研究，并且在其病理生理学方面积累了大量数据。然而，关于创伤性脑出血（tICH）的文献有限，需要对这一重要课题进行进一步研究。本综述将重点介绍脑出血中的一些细胞途径，着重探讨血红素毒性导致的继发性损伤机制以及sICH和tICH共有的凝血过程中的事件。
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