Fonarow Gregg C
Division of Cardiology, University of California Los Angeles (UCLA) David Geffen School of Medicine, and Ahmanson-UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, California, USA.
Rev Cardiovasc Med. 2006;7 Suppl 1:S3-11.
Heart failure (HF) remains a major public health problem, affecting 5 million patients in the United States. The personal burden of HF includes debilitating symptoms, activity limitations, frequent hospitalizations, arrhythmias, and increased mortality. Despite the compelling scientific evidence that angiotensin-converting enzyme inhibitors, beta-blockers, and aldosterone antagonists reduce hospitalizations and mortality in patients with HF, these life-prolonging therapies continue to be underutilized. Device therapy for HF, including implantable cardioverter defibrillators and cardiac resynchronization therapy, has recently been demonstrated to also result in substantial mortality reduction. Accurate evaluation of patients with HF is critical for the appropriate selection and monitoring of therapy to reduce symptoms as well as for the prevention of recurrent hospitalizations. A number of studies in a variety of clinical settings have documented that a significant proportion of patients with HF are not receiving treatment with guideline-recommended, evidence-based therapies. Treatment gaps have also been documented in providing other components of care for patients with HF, including assessment for congestion and patient education. Recent studies demonstrate that hospital-based systems can improve medical care and education of hospitalized HF patients and accelerate use of evidence-based, guideline-recommended therapies by administering them before hospital discharge. HF disease management programs have also been shown to improve HF treatment, resulting in substantial reduction in hospitalizations and mortality. Application of validated and reproducible noninvasive techniques to monitor patients with chronic HF is an important step in maximizing interventions to improve outcomes in this patient population. Further efforts are clearly needed to improve the monitoring of HF patients in the hospital and outpatient settings, as well as to ensure the implementation of effective strategies and systems that increase the use of evidence-based therapies, in order to reduce the substantial HF morbidity and mortality risk.
心力衰竭(HF)仍然是一个重大的公共卫生问题,在美国影响着500万患者。HF给个人带来的负担包括使人虚弱的症状、活动受限、频繁住院、心律失常以及死亡率增加。尽管有令人信服的科学证据表明,血管紧张素转换酶抑制剂、β受体阻滞剂和醛固酮拮抗剂可降低HF患者的住院率和死亡率,但这些延长生命的疗法仍未得到充分利用。HF的器械治疗,包括植入式心脏复律除颤器和心脏再同步治疗,最近已被证明也能显著降低死亡率。准确评估HF患者对于合理选择和监测治疗以减轻症状以及预防再次住院至关重要。在各种临床环境中的多项研究表明,相当一部分HF患者未接受指南推荐且基于证据的治疗。在为HF患者提供其他护理方面,包括充血评估和患者教育,也存在治疗差距。最近的研究表明,基于医院的系统可以改善住院HF患者的医疗护理和教育,并通过在出院前给予基于证据、指南推荐的疗法来加速其使用。HF疾病管理项目也已被证明可改善HF治疗,从而大幅降低住院率和死亡率。应用经过验证且可重复的非侵入性技术来监测慢性HF患者是最大限度地采取干预措施以改善该患者群体预后的重要一步。显然需要进一步努力改善对住院和门诊HF患者的监测,并确保实施有效的策略和系统以增加基于证据的疗法的使用,从而降低HF的高发病率和死亡风险。