Chin Ai-Vyrn, O'Connell Henry, Kirby Michael, Denihan Aisling, Bruce Irene, Walsh J B, Coakley David, Lawlor Brian A, Cunningham Conal
Mercer's Institute for Research on Ageing, St James's Hospital, James's Street, Dublin D8, Ireland.
Int J Geriatr Psychiatry. 2006 Dec;21(12):1150-5. doi: 10.1002/gps.1621.
Epidemiological studies suggest an association between health factors and dementia. The impact of these factors on the cognitive performance of the elderly population is unclear. Possible correlates of poor cognitive performance in a community dwelling elderly Irish population were examined.
Subjects were from a sample of individuals over 65 years agreeable to interview using the Geriatric Mental State (GMS)-Automated Geriatric Examination for Computed Assisted Taxonomy (AGECAT) package conducted at the subject's home. Associations between patient profiles and Mini Mental State Examination (MMSE) score were investigated in a multivariate model.
There were 793 subjects, 528 (66.6%) female with mean (s.d.) age 74.8 (6.7) yrs. Mean MMSE score was 26.5 (3.3). 169 (21.3%) were current smokers, 198 (25%) ex-smokers. Two hundred and twenty-four (28.3%) had a history of hypertension, 85 (10.7%) case level anxiety or depression, 51 (6.4%) stroke, ten0 (1.3%) epilepsy, nine (1.1%) Parkinson's disease and 29 (3.7%) dementia. Two hundred and fifty-five (32.2%) subjects were on psychotropic medications. Factors associated with MMSE score included age (p < or = 0.0001), diagnosis of dementia (p < or = 0.0001), socioeconomic group (p < or = 0.0001), education (p < or = 0.0001), previous stroke (p = 0.0013) and use of psychotropic medication (p = 0.03). Case level anxiety or depression (p = 0.99), Parkinson's disease (p = 0.52), epilepsy (p = 0.26), smoking status (p = 0.99) and hypertension (p = 0.34) were not found to be associated with cognitive performance.
Factors associated with cognitive performance included age, socioeconomic group, education, previous stroke and use of psychotropic medication. These factors should be adjusted for in studies assessing cognition in this population. Stroke prevention strategies and avoidance of psychotropic medication may benefit cognitive performance.
流行病学研究表明健康因素与痴呆之间存在关联。这些因素对老年人群认知表现的影响尚不清楚。本研究对爱尔兰社区居住老年人群中认知表现不佳的可能相关因素进行了调查。
研究对象来自65岁以上同意接受访谈的个体样本，在家中使用老年精神状态（GMS）-计算机辅助分类自动老年检查（AGECAT）软件包进行访谈。在多变量模型中研究患者特征与简易精神状态检查表（MMSE）评分之间的关联。
共有793名受试者，其中528名（66.6%）为女性，平均（标准差）年龄74.8（6.7）岁。平均MMSE评分为26.5（3.3）。169名（21.3%）为当前吸烟者，198名（25%）为既往吸烟者。224名（28.3%）有高血压病史，85名（10.7%）有病例级焦虑或抑郁，51名（6.4%）有中风史，10名（1.3%）有癫痫，9名（1.1%）有帕金森病，29名（3.7%）有痴呆。255名（32.2%）受试者正在服用精神药物。与MMSE评分相关的因素包括年龄（p≤或 = 0.0001）、痴呆诊断（p≤或 = 0.0001）、社会经济群体（p≤或 = 0.0001）、教育程度（p≤或 = 0.0001）、既往中风（p = 0.0013）和精神药物使用（p = 0.03）。未发现病例级焦虑或抑郁（p = 0.99）、帕金森病（p = 0.52）、癫痫（p = 0.26）、吸烟状况（p = 0.99）和高血压（p = 0.34）与认知表现相关。
与认知表现相关的因素包括年龄、社会经济群体、教育程度、既往中风和精神药物使用。在评估该人群认知的研究中应调整这些因素。中风预防策略和避免使用精神药物可能有益于认知表现。
