Van Orden R, Eggett D L, Franz K B
Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, Utah 84602, USA.
Magnes Res. 2006 Jun;19(2):93-101.
Increased white blood cell counts or leukocytosis have been observed primarily in young rats fed diets extremely low in Mg (< 60 ppm) and high in phosphorus (0.5 % P). We investigated the influence that acute and moderate Mg deficiencies have on blood leukocytes at high and low dietary phosphorus levels. For four weeks, male Sprague-Dawley rats (initially 7 weeks old) were fed diets containing 30, 60, 120, 208, or 850 ppm Mg and either 0.3 % or 0.5 % dietary phosphorus. Total leukocytes were increased in rats fed 30 ppm Mg (p < 0.0001), and the leukocyte subpopulation counts of lymphocytes, neutrophils, monocytes and eosinophils increased significantly only in the rats fed 30 ppm Mg (p < 0.0001). B-cells decreased significantly as a percentage of lymphocytes (p < 0.0093) as dietary Mg decreased. As total counts in blood, B-cells, CD4 and CD8 cells were significantly increased in the rats consuming the 30 ppm Mg diet. Dietary phosphorus only had an effect in combination with the lowest dietary Mg. These results demonstrate a threshold effect for increased leukocytes during a Mg deficiency of four weeks. A Mg deficiency of a longer duration may show different results.
主要在喂食极低镁含量（<60 ppm）和高磷含量（0.5% P）日粮的幼鼠中观察到白细胞计数增加或白细胞增多。我们研究了急性和中度镁缺乏在高磷和低磷日粮水平下对血液白细胞的影响。雄性Sprague-Dawley大鼠（初始7周龄）连续四周喂食含30、60、120、208或850 ppm镁以及0.3%或0.5%日粮磷的日粮。喂食30 ppm镁的大鼠总白细胞数增加（p<0.0001），仅在喂食30 ppm镁的大鼠中淋巴细胞、中性粒细胞、单核细胞和嗜酸性粒细胞的白细胞亚群计数显著增加（p<0.0001）。随着日粮镁含量降低，B细胞作为淋巴细胞的百分比显著下降（p<0.0093）。作为血液中的总数，B细胞、CD4和CD8细胞在食用30 ppm镁日粮的大鼠中显著增加。日粮磷仅在与最低日粮镁含量共同作用时才有影响。这些结果表明在四周镁缺乏期间白细胞增加存在阈值效应。持续时间更长的镁缺乏可能会显示不同的结果。
