Bai Long, Song Peiran, Su Jiacan
Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, China.
Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Biomater Transl. 2023 Dec 28;4(4):248-269. doi: 10.12336/biomatertransl.2023.04.005. eCollection 2023.
While bone tissue is known for its inherent regenerative abilities, various pathological conditions and trauma can disrupt its meticulously regulated processes of bone formation and resorption. Bone tissue engineering aims to replicate the extracellular matrix of bone tissue as well as the sophisticated biochemical mechanisms crucial for effective regeneration. Traditionally, the field has relied on external agents like growth factors and pharmaceuticals to modulate these processes. Although efficacious in certain scenarios, this strategy is compromised by limitations such as safety issues and the transient nature of the compound release and half-life. Conversely, bioactive elements such as zinc (Zn), magnesium (Mg) and silicon (Si), have garnered increasing interest for their therapeutic benefits, superior stability, and reduced biotic risks. Moreover, these elements are often incorporated into biomaterials that function as multifaceted bioactive components, facilitating bone regeneration via release on-demand. By elucidating the mechanistic roles and therapeutic efficacy of the bioactive elements, this review aims to establish bioactive elements as a robust and clinically viable strategy for advanced bone regeneration.
虽然骨组织以其固有的再生能力而闻名，但各种病理状况和创伤会扰乱其精心调控的骨形成和吸收过程。骨组织工程旨在复制骨组织的细胞外基质以及对有效再生至关重要的复杂生化机制。传统上，该领域依赖生长因子和药物等外部因素来调节这些过程。尽管在某些情况下有效，但这种策略受到安全性问题以及化合物释放的短暂性和半衰期等限制的影响。相反，锌（Zn）、镁（Mg）和硅（Si）等生物活性元素因其治疗益处、卓越的稳定性和降低的生物风险而越来越受到关注。此外，这些元素通常被纳入作为多方面生物活性成分起作用的生物材料中，通过按需释放促进骨再生。通过阐明生物活性元素的作用机制和治疗效果，本综述旨在将生物活性元素确立为一种强大且临床上可行的先进骨再生策略。
