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钙、镁、磷、氟和铅对骨组织的影响。

The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue.

机构信息

Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Żołnierska 54, 71-210 Szczecin, Poland.

Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.

出版信息

Biomolecules. 2021 Mar 28;11(4):506. doi: 10.3390/biom11040506.

DOI:10.3390/biom11040506
PMID:33800689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8066206/
Abstract

Bones are metabolically active organs. Their reconstruction is crucial for the proper functioning of the skeletal system during bone growth and remodeling, fracture healing, and maintaining calcium-phosphorus homeostasis. The bone metabolism and tissue properties are influenced by trace elements that may act either indirectly through the regulation of macromineral metabolism, or directly by affecting osteoblast and osteoclast proliferation or activity, or through becoming part of the bone mineral matrix. This study analyzes the skeletal impact of macroelements (calcium, magnesium, phosphorus), microelements (fluorine), and heavy metals (lead), and discusses the concentration of each of these elements in the various bone tissues.

摘要

骨头是代谢活跃的器官。它们的重建对于骨骼系统在骨骼生长和重塑、骨折愈合以及维持钙磷平衡期间的正常功能至关重要。微量元素会影响骨骼代谢和组织特性,其作用方式既可以是通过调节宏量矿物质代谢间接影响,也可以是通过直接影响成骨细胞和破骨细胞的增殖或活性来影响,或者通过成为骨矿物质基质的一部分来影响。本研究分析了常量元素(钙、镁、磷)、微量元素(氟)和重金属(铅)对骨骼的影响,并讨论了这些元素在各种骨组织中的浓度。

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Biomolecules. 2021 Mar 28;11(4):506. doi: 10.3390/biom11040506.
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Lead Toxicity and Pollution in Poland.波兰的铅毒性与污染。
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Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism.鉴定人类破骨细胞-成骨细胞偶联因子揭示了骨骼与能量代谢之间的联系。
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The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress.重金属铅和镉通过诱导氧化应激对人成骨细胞产生细胞毒性。
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Fluorine-contained hydroxyapatite suppresses bone resorption through inhibiting osteoclasts differentiation and function in vitro and in vivo.含氟羟基磷灰石通过体外和体内抑制破骨细胞分化和功能来抑制骨吸收。
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Osteocalcin-A Versatile Bone-Derived Hormone.骨钙素-A:一种多功能的骨源性激素。
Front Endocrinol (Lausanne). 2019 Jan 10;9:794. doi: 10.3389/fendo.2018.00794. eCollection 2018.
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