Crich David, Bowers Albert A
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
Org Lett. 2006 Sep 14;8(19):4327-30. doi: 10.1021/ol061706m.
A naturally occurring beta-(1-->3)-D-rhamnotetraose has been constructed under conditions of sequential beta-selective mannosylation controlled by the 4,6-O-[1-cyano-2-(2-iodophenyl)-ethylidene] protecting group. The route is concise, proceeding through a late-stage radical deoxygenation that successfully uncovers all four deoxy subunits at once.
一种天然存在的β-(1→3)-D-鼠李糖四糖已在由4,6-O-[1-氰基-2-(2-碘苯基)-亚乙基]保护基控制的连续β-选择性甘露糖基化条件下构建而成。该路线简洁,通过后期自由基脱氧反应一次性成功揭示了所有四个脱氧亚基。