采用2'-羧基苄基糖苷合成丹麦幽门螺杆菌菌株非典型O抗原多糖的三糖重复单元。

Synthesis of the trisaccharide repeating unit of the atypical O-antigen polysaccharide from Danish Helicobacter pylori strains employing the 2'-carboxybenzyl glycoside.

作者信息

Kwon Yong Tae, Lee Yong Joo, Lee Kyunghoon, Kim Kwan Soo

机构信息

Center for Bioactive Molecular Hybrids and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.

出版信息

Org Lett. 2004 Oct 28;6(22):3901-4. doi: 10.1021/ol048648u.

DOI:10.1021/ol048648u

PMID:15496059

Abstract

[reaction: see text] Synthesis of the unique trisaccharide repeating unit of the O-polysaccharide of the lipopolysaccharide from Danish Helicobacter pylori strains has been accomplished. Key steps include the coupling of three monosaccharide moieties by glycosylations employing the 2'-carboxybenzyl glycoside method. Also presented is a method for the synthesis of the novel branched sugar, 3-C-methyl-D-mannose, which is one of three monosaccharide components.

摘要

[反应：见正文] 已完成丹麦幽门螺杆菌菌株脂多糖O-多糖独特三糖重复单元的合成。关键步骤包括采用2'-羧基苄基糖苷法通过糖基化反应连接三个单糖部分。还介绍了一种合成新型支链糖3-C-甲基-D-甘露糖的方法，它是三个单糖成分之一。