Asano Y, Ihn H, Kubo M, Jinnin M, Mimura Y, Ashida R, Tamaki K
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Clin Exp Rheumatol. 2006 Jul-Aug;24(4):394-9.
To investigate the clinical significance of serum matrix metalloproteinase-13 (MMP-13) levels in patients with localized scleroderma (LSc).
Serum MMP-13 levels were determined by using a peptide substrate cleavage assay in 10 patients with generalized morphea, 10 with linear scleroderma, 10 with morphea, and 10 normal controls.
The serum MMP-13 levels in patients with LSc were lower than those in normal controls, but there was no significant difference (64.9 +/- 19.9 versus 73.2 +/- 11.5, p = 0.058). Serum MMP-13 levels in patients with generalized morphea were significantly lower than those in normal controls (54.0 +/- 18.7 versus 73.2 +/- 11.5 ng/ml; p < 0.01). Serum levels of MMP-13 were comparable among normal controls, the patients with linear scleroderma, and those with morphea. The prevalence of muscle involvement was significantly greater in the LSc patients with decreased MMP-13 levels compared with those with normal MMP-13 levels (50% versus 8%, p < 0.05). Serum MMP-13 levels were significantly inversely correlated with the number of linear lesions (r = 0.366, p < 0.05) and the number of involved body areas (r = 0.552, p < 0.005) in patients with LSc, while there was no significant correlation between serum MMP-13 levels and the number of plaque lesions. Furthermore, there was significant inverse correlation between serum MMP-13 levels and the number of involved body areas in patients with generalized morphea (r = 0.631, p < 0.05).
The serum MMP-13 levels may reflect the disease severity in patients with LSc, especially generalized morphea, the severest form of this disorder.
探讨局限性硬皮病（LSc）患者血清基质金属蛋白酶-13（MMP-13）水平的临床意义。
采用肽底物裂解试验测定10例泛发性硬斑病患者、10例线状硬皮病患者、10例硬斑病患者和10例正常对照者的血清MMP-13水平。
LSc患者血清MMP-13水平低于正常对照者，但差异无统计学意义（64.9±19.9对73.2±11.5，p = 0.058）。泛发性硬斑病患者血清MMP-13水平显著低于正常对照者（54.0±18.7对73.2±11.5 ng/ml；p < 0.01）。正常对照者、线状硬皮病患者和硬斑病患者的血清MMP-13水平相当。与MMP-13水平正常的LSc患者相比，MMP-13水平降低的LSc患者肌肉受累的患病率显著更高（50%对8%，p < 0.05）。LSc患者血清MMP-13水平与线状皮损数量（r = 0.366，p < 0.05）和受累身体部位数量（r = 0.552，p < 0.005）显著负相关，而血清MMP-13水平与斑块状皮损数量之间无显著相关性。此外，泛发性硬斑病患者血清MMP-13水平与受累身体部位数量之间存在显著负相关（r = 0.631，p < 0.05）。
血清MMP-13水平可能反映LSc患者，尤其是泛发性硬斑病（该病最严重的形式）的疾病严重程度。
