Dhanasekaran Muralikrishnan, Uthayathas Subramaniam, Karuppagounder Senthilkumar S, Parameshwaran Kodeeswaran, Suppiramaniam Vishnu, Ebadi Manuchair, Brown-Borg Holly M
Department of Pharmacal Sciences, Division of Pharmacology and Toxicology, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
Brain Res. 2006 Nov 6;1118(1):251-4. doi: 10.1016/j.brainres.2006.08.020. Epub 2006 Sep 7.
We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 microM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
我们评估了依布硒仑对人源SH-SY5Y多巴胺能神经元细胞的作用，并确定作为谷胱甘肽过氧化物酶模拟物的依布硒仑是否能保护小鼠免受MPTP诱导的多巴胺耗竭。依布硒仑（10 - 100微摩尔）剂量依赖性地抑制SH-SY5Y细胞的增殖。依布硒仑未引起任何行为变化，也未阻断MPTP诱导的震颤和运动不能。依布硒仑对单胺氧化酶活性没有影响，也不能保护纹状体免受MPTP诱导的多巴胺耗竭。
