Fiedler W, Weh H J, Suciu E, Wittlief C, Stocking C, Hossfeld D K
Department of Oncology/Hematology, University Hospital Eppendorf, Hamburg, F.R.G.
Leukemia. 1990 Jul;4(7):462-5.
Constitutive secretion of interleukin-6 (IL-6) has been proposed as a mechanism of transformation in multiple myeloma. We therefore studied 15 patients with this disease for rearrangements of the IL-6 and IL-6 receptor genes. Two patients with altered IL-6 genes were identified. Chromosome analysis revealed aberrations of chromosome 7, where the IL-6 gene resides, in only these two patients, but not in others without IL-6 rearrangements. In one of these patients, constitutive IL-6 m-RNA expression was observed. No alterations of IL-6 receptor genes were detected.
白细胞介素-6（IL-6）的组成型分泌已被提出是多发性骨髓瘤转化的一种机制。因此，我们研究了15例该疾病患者的IL-6和IL-6受体基因重排情况。鉴定出2例IL-6基因改变的患者。染色体分析显示，仅在这2例患者中发现了IL-6基因所在的7号染色体畸变，而在其他无IL-6重排的患者中未发现。在其中1例患者中，观察到了组成型IL-6信使核糖核酸表达。未检测到IL-6受体基因的改变。
