Suzuki Noriyoshi, Sato Yoshikazu, Hisasue Shin-Ichi, Kato Ryuichi, Suzuki Kazuhiro, Tsukamoto Taiji
Department of Urology, Sapporo Medical University School of Medicine, S1-W16 Chuo-ku, Sapporo, Hokkaido, Japan. .
J Androl. 2007 Mar-Apr;28(2):218-22. doi: 10.2164/jandrol.106.000695. Epub 2006 Sep 6.
We studied the effects of castration and testosterone (T) replacement on intracavernous pressure (ICP) elicited with electrical stimulation of the medial preoptic area (MPOA) and cavernous nerve (CN) in male rats. We measured the ICP during electrical stimulation of the MPOA and CN in castrated male rats with and without testosterone replacement. The experimental group consisted of 20-week-old male rats at 2 weeks (n=8), 4 weeks (n=8) and 8 weeks (n=8) after castration, and at 8 weeks after castration with T replacement (n=4). Intact 20-week-old rats (n=8) served as controls. The erectile response was expressed as the ICP/blood pressure (BP) ratio. The ICP/BP ratios during CN stimulation of the animals at 2, 4, and 8 weeks after castration were significantly lower than those of the intact animals. However, the erectile responses were not eliminated. In contrast to these peripherally evoked responses, erectile responses elicited by electrical stimulation of the MPOA were eliminated following castration. After testosterone replacement, both erectile responses were restored. Testosterone plays important roles in both the central and peripheral neural pathways for the maintenance and restoration of erectile capacity. The central control of erection shows more extensive changes following testosterone replacement than the peripheral control.
我们研究了去势和睾酮（T）替代对雄性大鼠经电刺激内侧视前区（MPOA）和海绵体神经（CN）所诱发的海绵体内压（ICP）的影响。我们在有或无睾酮替代的去势雄性大鼠电刺激MPOA和CN期间测量了ICP。实验组包括去势后2周（n = 8）、4周（n = 8）和8周（n = 8）以及去势后8周进行T替代（n = 4）的20周龄雄性大鼠。完整的20周龄大鼠（n = 8）作为对照。勃起反应以ICP/血压（BP）比值表示。去势后2周、4周和8周的动物在CN刺激期间的ICP/BP比值显著低于完整动物。然而，勃起反应并未消除。与这些外周诱发反应相反，去势后电刺激MPOA所诱发的勃起反应被消除。睾酮替代后，两种勃起反应均得以恢复。睾酮在维持和恢复勃起能力的中枢和外周神经通路中均发挥重要作用。睾酮替代后，勃起的中枢控制比外周控制显示出更广泛的变化。
