Nutt John G
Parkinson Center of Oregon, Oregon Health & Science University, Portland, Oregon 97239-3098, USA.
Mov Disord. 2007 Jan;22(1):1-9. doi: 10.1002/mds.21060.
Continuous dopaminergic stimulation (CDS) is a treatment strategy hypothesized to avoid or reduce the motor complications of long-term levodopa therapy, motor fluctuations, and dyskinesia, by preventing or reversing sensitization induced by pulsatile dopaminergic stimulation. The CDS hypothesis is itself based on several hypotheses. First, tonic dopaminergic stimulation is physiological. Second, sensitization is undesirable and should be reversed. Third, reduction of off time and dyskinesia can be induced simultaneously. Finally, clinical studies substantiate the CDS hypothesis. The evidence for these hypotheses is reviewed, and the need for randomized clinical trials that rigorously test the CDS hypothesis is emphasized.
持续多巴胺能刺激（CDS）是一种治疗策略，其假设通过预防或逆转脉冲式多巴胺能刺激所诱导的敏化作用，来避免或减少长期左旋多巴治疗的运动并发症、运动波动及异动症。CDS假说本身基于若干假说。其一，持续性多巴胺能刺激是生理性的。其二，敏化作用是不良的，应予以逆转。其三，可同时诱导关期时间及异动症的减少。最后，临床研究证实了CDS假说。本文对这些假说的证据进行了综述，并强调了开展严格检验CDS假说的随机临床试验的必要性。
