Celik Suat Erol, Oztürk Hülya, Tolunay Sahsine
Department of Neurosurgery, Beyoglu State Hospital, Istanbul, Turkey.
J Neurotrauma. 2006 Sep;23(9):1355-65. doi: 10.1089/neu.2006.23.1355.
This study was undertaken to evaluate the therapeutic effect of hypothermia and dizocilpine maleate in traumatic brain injury (TBI) on newborn rats. After induction of TBI, physiologic and histopathological assessments were performed on both the control and therapeutic groups to evaluate the effects of both agents. Rats were assigned into four groups as follows: normothermic (n = 23), hypothermic (n = 18), normothermia plus dizocilpine maleate (n = 18) and hypothermia plus dizocilpine maleate (n = 18). All the rats were injured using a weight-drop head injury model, artificially ventilated with a 33% O(2) and 66% NO(2) mixture, and physiological parameters, intracranial pressure, and brain and rectal temperatures were recorded. Mortality, physiological, neurological parameters, and histopathological changes were assessed after 24 h. As a result, intracranial pressure, cerebral perfusion pressure, morbidity, weight loss, and microscopic changes were significantly worse in the normothermic group (p <0.05). There was no statistical difference between other groups (p > 0.05). Hypothermia and dizocilpine maleate displayed similar neuroprotective effects in TBI on newborn rats, but no additive effect was observed.
本研究旨在评估亚低温及马来酸二氮卓对新生大鼠创伤性脑损伤（TBI）的治疗效果。在诱导TBI后，对对照组和治疗组进行生理及组织病理学评估，以评价两种药物的作用。大鼠被分为以下四组：正常体温组（n = 23）、亚低温组（n = 18）、正常体温加马来酸二氮卓组（n = 18）和亚低温加马来酸二氮卓组（n = 18）。所有大鼠均采用重物撞击头部损伤模型致伤，用33% O₂和66% NO₂混合气进行人工通气，并记录生理参数、颅内压以及脑和直肠温度。24小时后评估死亡率、生理、神经学参数及组织病理学变化。结果显示，正常体温组的颅内压、脑灌注压、发病率、体重减轻及微观变化明显更差（p <0.05）。其他组之间无统计学差异（p >0.05）。亚低温及马来酸二氮卓在新生大鼠TBI中显示出相似的神经保护作用，但未观察到相加效应。
