Lapierre J, Piguet B, Chastanet B
Sem Hop. 1975 Feb 14;51(8):531-8.
Muco-cutaneous leishmaniasis is now more frequently observed in France owing to population movements. One should learn to recognise the disease, the various aspects of which are presented here (7 cases). They recall the necessity of associating direct search for leishmania in the serous exsudate from the lesions or on histological sections, routine culture of swabs on agar jelly en riched with blood and on heart-brain blood medium. The immunoglobulin estimation sometimes revealed significant increase in their levels, but the sero-immunologic reactions by the indirect immuno-fluorescent method, were all negative. The best treatment is N-methylglucamine antimoniate by intradermal injection under the lesions or, in some cases, the parenteral route. On the other hand, metronidazole does not seem to be efficacious in skin leishmaniasis in this part of the world.
由于人口流动，法国现在更频繁地观察到皮肤黏膜利什曼病。人们应该学会识别这种疾病，这里介绍了其各个方面（7例）。它们提醒人们有必要在病变的浆液渗出物中或组织切片上直接寻找利什曼原虫，常规将拭子接种在富含血液的琼脂冻和心脑血培养基上进行培养。免疫球蛋白测定有时显示其水平显著升高，但间接免疫荧光法的血清免疫反应均为阴性。最佳治疗方法是在病变部位皮下注射N-甲基葡糖胺锑酸盐，或在某些情况下采用胃肠外给药途径。另一方面，在世界这一地区，甲硝唑似乎对皮肤利什曼病无效。
