从成年和衰老的Wistar大鼠肝脏分离的肝细胞的RNA合成。
RNA synthesis by hepatocytes isolated from adult and senescent Wistar rat liver.
作者信息
Park G H, Buetow D E
机构信息
Department of Physiology and Biophysics, University of Illinois, Urbana.
出版信息
Gerontology. 1990;36(2):76-83. doi: 10.1159/000213180.
PMID:1695885
Abstract
The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.
摘要
与成年（12个月）雌性Wistar大鼠相比，从衰老（25个月）大鼠分离的肝细胞中，总RNA、聚腺苷酸（poly(A)+）RNA和信使核糖核酸（mRNA）的合成速率分别降低了41%、49%和42%。转录连续分析结果表明，转录起始能力受损在很大程度上导致了衰老肝细胞RNA合成的减少。
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