Frolkis V V, Paramonova G I, Goldstein N B
Institute of Gerontology AMW, USSR, Kiev.
Z Alternsforsch. 1989 Jan-Feb;44(1):3-5.
Plasmic membrane hyperpolarization resulted in a significant activation of the cell genome and a stimulation of the synthesis of total RNA and protein of hepatocytes. Changes in the level of membrane potential are thought to be one of the mechanisms of regulation of cell's genetic apparatus. In old age the stimulating effect of hyperpolarization is weakened that may be a cause of a change in protein biosynthesis.
质膜超极化导致细胞基因组显著激活，并刺激肝细胞总RNA和蛋白质的合成。膜电位水平的变化被认为是细胞遗传装置调节机制之一。在老年时，超极化的刺激作用减弱，这可能是蛋白质生物合成发生变化的一个原因。
