van Zwieten Pieter A, Mancia Giuseppe
Departments of Pharmacotherapy, Cardiology, and Cardiothoracic Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Semin Cardiothorac Vasc Anesth. 2006 Sep;10(3):206-14. doi: 10.1177/1089253206291327.
Metabolic syndrome is characterized by a clustering of cardiovascular and metabolic risk factors. This syndrome is now widely recognized as a distinct pathologic entity. It is receiving a great deal of attention in the medical literature and also in the lay press. People with metabolic syndrome have a clustering of the following risk factors, including detrimental changes in glucose tolerance and insulin resistance, abdominal (visceral) obesity, atherogenic dyslipidemia, and hypertension. Metabolic syndrome is associated with important cardiovascular and cerebrovascular and metabolic risks. Prevention and treatment are therefore of great importance. Preventive measures involving lifestyle are mandatory. In addition, metabolic syndrome patients will require pharmacologic treatment, usually for the rest of their lives. Complex patterns of drug treatment are required. This review provides an extensive and critical review of the drug treatment of this complex pathologic entity.
代谢综合征的特征是心血管和代谢危险因素聚集。这种综合征现在已被广泛认可为一种独特的病理实体。它在医学文献以及大众媒体中都受到了大量关注。患有代谢综合征的人具有以下危险因素聚集，包括糖耐量和胰岛素抵抗的有害变化、腹部（内脏）肥胖、致动脉粥样硬化血脂异常和高血压。代谢综合征与重要的心血管、脑血管和代谢风险相关。因此，预防和治疗非常重要。涉及生活方式的预防措施是必需的。此外，代谢综合征患者通常需要终生进行药物治疗。需要复杂的药物治疗方案。本综述对这种复杂病理实体的药物治疗进行了广泛而批判性的综述。
