Lender Dan, Sysko Suzanne K
Division of Endocrinology, Diabetes, and Nutrition, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA.
Pharmacotherapy. 2006 May;26(5 Pt 2):3S-12S. doi: 10.1592/phco.26.5part2.3S.
The metabolic syndrome is a public health concern because its prevalence is increasing in the United States, and it is associated with cardiovascular morbidity and mortality. We discuss epidemiologic trends in and causes of the metabolic syndrome. The relationships among the cardiometabolic risk factors that contribute to the metabolic syndrome-obesity, insulin resistance, proinflammatory and prothrombotic states, atherogenic dyslipidemia, and hypertension-and between these risk factors and cardiovascular morbidity and mortality are explained. Currently available interventions to modify these risk factors and the importance of preventive strategies and early detection efforts are also addressed.
代谢综合征是一个公共卫生问题，因为其在美国的患病率正在上升，并且它与心血管疾病的发病率和死亡率相关。我们讨论了代谢综合征的流行病学趋势及其成因。阐述了导致代谢综合征的心脏代谢危险因素（肥胖、胰岛素抵抗、促炎和促血栓形成状态、致动脉粥样硬化血脂异常和高血压）之间的关系，以及这些危险因素与心血管疾病发病率和死亡率之间的关系。还探讨了目前可用于改变这些危险因素的干预措施以及预防策略和早期检测工作的重要性。
