Knight Ann, Ekbom Anders, Brandt Lena, Askling Johan
Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden.
J Rheumatol. 2006 Oct;33(10):2060-3.
Studies of Wegener's granulomatosis (WG) since the late 1980s indicate a probable increase in incidence of unknown cause and significance, possibly related to antineutrophil cytoplasmic antibody (ANCA) testing. To extend these observations and to include calendar periods before ANCA was introduced, we assessed time trends in the incidence of WG in Sweden in the period 1975-2001.
In the population-based Swedish Inpatient Register, we identified 1938 individuals diagnosed with WG in the period 1975-2001, and calculated the annual age and sex adjusted incidences.
The incidence increased from 0.33 (95% CI 0.28-0.39) in the period 1975-85 to 0.77 (95% CI 0.69-0.85) in 1986-90, to 1.19 (95% CI 1.12-1.26) in 1991-2001, resulting in a mean incidence of 0.78 (95% CI 0.74-0.82).
WG displays a strong temporal trend. While the increase coincides to some extent with the implementation of ANCA testing, suggestive of increased disease recognition, ANCA testing remains an incomplete explanation as increasing incidences were noted before as well as after their introduction.
20世纪80年代末以来关于韦格纳肉芽肿（WG）的研究表明，其发病率可能因不明原因而增加，且具有重要意义，这可能与抗中性粒细胞胞浆抗体（ANCA）检测有关。为了拓展这些观察结果并纳入ANCA检测引入之前的时间段，我们评估了1975 - 2001年瑞典WG发病率的时间趋势。
在基于人群的瑞典住院患者登记系统中，我们确定了1975 - 2001年期间1938例被诊断为WG的个体，并计算了年龄和性别调整后的年发病率。
发病率从1975 - 1985年期间的0.33（95%可信区间0.28 - 0.39）增至1986 - 1990年的0.77（95%可信区间0.69 - 0.85），再到1991 - 2001年的1.19（95%可信区间1.12 - 1.26），平均发病率为0.78（95%可信区间0.74 - 0.82）。
WG呈现出明显的时间趋势。虽然发病率的增加在一定程度上与ANCA检测的实施相吻合，提示疾病认知度提高，但ANCA检测仍不能完全解释发病率的上升，因为在其引入之前及之后均有发病率增加的情况。
