氯化锶对体内骨髓细胞的致断裂活性。

Clastogenic activity of strontium chloride on bone marrow cells in vivo.

作者信息

Ghosh S, Talukder G, Sharma A

机构信息

Department of Botany, University of Calcutta, India.

出版信息

Biol Trace Elem Res. 1990 Apr;25(1):51-6. doi: 10.1007/BF02990264.

DOI:10.1007/BF02990264

PMID:1696112

Abstract

Oral administration of different concentrations of Strontium chloride to laboratory bred mice in vivo induced chromosomal aberrations in bone marrow cell metaphase preparations. The degree of clastogenicity was directly proportional to concentration used at 6, 12, and 24 h of treatment. Duration of treatment could only be related positively in the lower doses. The females showed greater susceptibility than the males at all concentrations used.

摘要

给实验室饲养的小鼠体内口服不同浓度的氯化锶，可在骨髓细胞中期制备物中诱导染色体畸变。在处理的6小时、12小时和24小时，致断裂性程度与所用浓度直接成正比。仅在较低剂量下，处理持续时间才呈正相关。在所有使用的浓度下，雌性小鼠比雄性小鼠表现出更高的敏感性。