Tanikawa S, Nose M, Aoki Y, Tsuneoka K, Shikita M, Nara N
Division of Radiation Health, National Institute of Radiological Sciences, Chiba, Japan.
Blood. 1990 Aug 1;76(3):445-9.
We studied the effects of intraperitoneal injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) according to various administration schedules on the recovery of spleen colony-forming units (CFU-S) and peripheral blood counts, and on the survival of irradiated mice. The sooner and more frequently the mice were injected with rhG-CSF after irradiation, the more enhanced the recovery of CFU-S in bone marrow was obtained on day 7. Twice-daily injections of rhG-CSF from day 0 to day 2 significantly enhanced the recovery of platelets and hematocrit, but two injections of rhG-CSF on only day 0 did not. Twice-daily injections of rhG-CSF from day 0 to day 6 enhanced the recovery of platelets more effectively than twice-daily injections of rhG-CSF from day 1 to day 7, and increased the survival of irradiated mice more effectively than any other examined administration schedules. Twice-daily injections of rhG-CSF from day 0 to day 6 were significantly effective in enhancing the survival of mice irradiated with 8.5-, 9.0-, and 9.5-Gy x-rays, although not effective after irradiation of 10.5-Gy x-rays.
我们研究了根据不同给药方案腹腔注射重组人粒细胞集落刺激因子（rhG-CSF）对脾集落形成单位（CFU-S）恢复、外周血细胞计数以及对受辐照小鼠存活情况的影响。辐照后小鼠越早且越频繁地注射rhG-CSF，在第7天时骨髓中CFU-S的恢复就越显著。从第0天到第2天每天注射两次rhG-CSF可显著提高血小板和血细胞比容的恢复，但仅在第0天注射两次rhG-CSF则无此效果。从第0天到第6天每天注射两次rhG-CSF比从第1天到第7天每天注射两次rhG-CSF更有效地促进血小板恢复，并且比其他任何检查的给药方案更有效地提高受辐照小鼠的存活率。从第0天到第6天每天注射两次rhG-CSF在提高受8.5、9.0和9.5 Gy X射线辐照小鼠的存活率方面具有显著效果，尽管在受10.5 Gy X射线辐照后无效。
