泊沙康唑用于治疗难治性侵袭性真菌病。

Posaconazole for treatment of refractory invasive fungal disease.

作者信息

Notheis G, Tarani L, Costantino F, Jansson A, Rosenecker J, Friederici D, Belohradsky B H, Reinhardt D, Seger R, Schweinitz D V, Wintergerst Uwe

机构信息

University Childrens Hospital, Munich, Germany.

出版信息

Mycoses. 2006;49 Suppl 1:37-41. doi: 10.1111/j.1439-0507.2006.01301.x.

DOI:10.1111/j.1439-0507.2006.01301.x

PMID:16961581

Abstract

Invasive fungal infections are usually associated with immunocompromised states About 40-60% of these patients are refractory to standard antifungal therapy We describe the effect of posaconazole in the treatment of a 12 years-old girl with uncontrolled diabetes mellitus with life-threatening cerebral mucor mycosis and a 4 year old girl boy with chronic granulomatous disease presenting with invasive Aspergillus nidulans infection.

摘要

侵袭性真菌感染通常与免疫功能低下状态有关。这些患者中约40%-60%对标准抗真菌治疗无效。我们描述了泊沙康唑对一名患有危及生命的脑毛霉菌病且糖尿病控制不佳的12岁女孩以及一名患有慢性肉芽肿病并伴有侵袭性构巢曲霉感染的4岁男童的治疗效果。