Tavakoli Mahin, Hedayati Mohammad Taghi, Mirhendi Hossein, Nouripour-Sisakht Sadegh, Hedayati Newsha, Saghafi Fatemeh, Mamishi Setareh
Student Research Committee, Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Curr Med Mycol. 2020;6(1):55-60. doi: 10.18502/cmm.6.1.2551.
Invasive aspergillosis (IA) of the central nervous system (CNS) is a devastating complication which is rarely reported in immunocompromised children. In this case presentation, we reported a rare and fatal IA with spinal cord involvement in a 10-year-old child with X-linked chronic granulomatosis disease (CGD).
The child had a previous history of pulmonary tuberculosis. A cervical spine X-ray revealed the involvement of cervical vertebrae (T4/T5) and s causing spinal cord compression and epidural abscess The patient underwent a decompressive laminectomy and mass removal. The histopathology and culture results suggested IA. Despite the aggressive and prolonged therapy, he died within one year. was identified as the causative agent based on morphological and molecular studies.
This synopsis represents the aggressive behavior of infection caused by in the CGD patient.
中枢神经系统（CNS）侵袭性曲霉病（IA）是一种毁灭性并发症，在免疫功能低下的儿童中鲜有报道。在本病例报告中，我们报告了一名患有X连锁慢性肉芽肿病（CGD）的10岁儿童发生罕见且致命的IA并累及脊髓的情况。
该儿童既往有肺结核病史。颈椎X线检查显示颈椎（T4/T5）受累，导致脊髓受压和硬膜外脓肿。患者接受了减压性椎板切除术和肿物切除术。组织病理学和培养结果提示为IA。尽管进行了积极且长期的治疗，但他在一年内死亡。根据形态学和分子学研究确定 为病原体。
本病例摘要体现了CGD患者中由 引起的感染的侵袭性。
